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Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation
Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330150/ https://www.ncbi.nlm.nih.gov/pubmed/28241820 http://dx.doi.org/10.1186/s12931-017-0526-9 |
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author | Chai, Amanda B. Ammit, Alaina J. Gelissen, Ingrid C. |
author_facet | Chai, Amanda B. Ammit, Alaina J. Gelissen, Ingrid C. |
author_sort | Chai, Amanda B. |
collection | PubMed |
description | Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pulmonary inflammation. Three ATP-binding cassette (ABC) transporters are found in the mammalian lung – ABCA1, ABCG1 and ABCA3 – that are involved in movement of cholesterol and phospholipids from lung cells. The aim of this review is to corroborate the current evidence for the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation. Here, we summarise results from murine knockout studies, human diseases associated with ABC transporter mutations, and in vitro studies. Disruption to ABC transporter activity results in lipid accumulation and elevated levels of inflammatory cytokines in lung tissue. Furthermore, these ABC-knockout mice exhibit signs of respiratory distress. ABC lipid transporters appear to have a crucial and protective role in the lung. However, our knowledge of the underlying molecular mechanisms for these benefits requires further attention. Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases. |
format | Online Article Text |
id | pubmed-5330150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53301502017-03-03 Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation Chai, Amanda B. Ammit, Alaina J. Gelissen, Ingrid C. Respir Res Review Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pulmonary inflammation. Three ATP-binding cassette (ABC) transporters are found in the mammalian lung – ABCA1, ABCG1 and ABCA3 – that are involved in movement of cholesterol and phospholipids from lung cells. The aim of this review is to corroborate the current evidence for the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation. Here, we summarise results from murine knockout studies, human diseases associated with ABC transporter mutations, and in vitro studies. Disruption to ABC transporter activity results in lipid accumulation and elevated levels of inflammatory cytokines in lung tissue. Furthermore, these ABC-knockout mice exhibit signs of respiratory distress. ABC lipid transporters appear to have a crucial and protective role in the lung. However, our knowledge of the underlying molecular mechanisms for these benefits requires further attention. Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases. BioMed Central 2017-02-28 2017 /pmc/articles/PMC5330150/ /pubmed/28241820 http://dx.doi.org/10.1186/s12931-017-0526-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chai, Amanda B. Ammit, Alaina J. Gelissen, Ingrid C. Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title | Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title_full | Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title_fullStr | Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title_full_unstemmed | Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title_short | Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation |
title_sort | examining the role of abc lipid transporters in pulmonary lipid homeostasis and inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330150/ https://www.ncbi.nlm.nih.gov/pubmed/28241820 http://dx.doi.org/10.1186/s12931-017-0526-9 |
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