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An epigenome-wide association analysis of cardiac autonomic responses among a population of welders
DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330442/ https://www.ncbi.nlm.nih.gov/pubmed/28075199 http://dx.doi.org/10.1080/15592294.2016.1270486 |
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author | Zhang, Jinming Liu, Zhonghua Umukoro, Peter E. Cavallari, Jennifer M. Fang, Shona C. Weisskopf, Marc G. Lin, Xihong Mittleman, Murray A. Christiani, David C. |
author_facet | Zhang, Jinming Liu, Zhonghua Umukoro, Peter E. Cavallari, Jennifer M. Fang, Shona C. Weisskopf, Marc G. Lin, Xihong Mittleman, Murray A. Christiani, David C. |
author_sort | Zhang, Jinming |
collection | PubMed |
description | DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in cardiac autonomic responses. Cardiac autonomic responses were measured with two novel markers: acceleration capacity (AC) and deceleration capacity (DC). We examined DNA methylation levels at more than 472,506 CpG probes through the Illumina Infinium HumanMethylation450 BeadChip assay. We conducted separate linear mixed models to examine associations of DNA methylation levels at each CpG with AC and DC. One CpG (cg26829071) located in the GPR133 gene was negatively associated with DC values after multiple testing corrections through false discovery rate. Our study suggests the potential functional importance of methylation in cardiac autonomic responses. Findings from the current study need to be replicated in future studies in a larger population. |
format | Online Article Text |
id | pubmed-5330442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-53304422017-03-07 An epigenome-wide association analysis of cardiac autonomic responses among a population of welders Zhang, Jinming Liu, Zhonghua Umukoro, Peter E. Cavallari, Jennifer M. Fang, Shona C. Weisskopf, Marc G. Lin, Xihong Mittleman, Murray A. Christiani, David C. Epigenetics Brief Report DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in cardiac autonomic responses. Cardiac autonomic responses were measured with two novel markers: acceleration capacity (AC) and deceleration capacity (DC). We examined DNA methylation levels at more than 472,506 CpG probes through the Illumina Infinium HumanMethylation450 BeadChip assay. We conducted separate linear mixed models to examine associations of DNA methylation levels at each CpG with AC and DC. One CpG (cg26829071) located in the GPR133 gene was negatively associated with DC values after multiple testing corrections through false discovery rate. Our study suggests the potential functional importance of methylation in cardiac autonomic responses. Findings from the current study need to be replicated in future studies in a larger population. Taylor & Francis 2017-01-11 /pmc/articles/PMC5330442/ /pubmed/28075199 http://dx.doi.org/10.1080/15592294.2016.1270486 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Brief Report Zhang, Jinming Liu, Zhonghua Umukoro, Peter E. Cavallari, Jennifer M. Fang, Shona C. Weisskopf, Marc G. Lin, Xihong Mittleman, Murray A. Christiani, David C. An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title_full | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title_fullStr | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title_full_unstemmed | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title_short | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
title_sort | epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330442/ https://www.ncbi.nlm.nih.gov/pubmed/28075199 http://dx.doi.org/10.1080/15592294.2016.1270486 |
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