Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists

Peroxisome proliferator-activated receptor γ (PPARγ) is a well-known target for thiazolidinedione antidiabetic drugs. In this paper, we present the synthesis and biological evaluation of a series of dihydropyrano[2,3-c]pyrazole derivatives as a novel family of PPARγ partial agonists. Two analogues w...

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Detalles Bibliográficos
Autores principales: Qvortrup, Katrine, Jensen, Jakob F., Sørensen, Mikael S., Kouskoumvekaki, Irene, Petersen, Rasmus K., Taboureau, Olivier, Kristiansen, Karsten, Nielsen, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330453/
https://www.ncbi.nlm.nih.gov/pubmed/28245241
http://dx.doi.org/10.1371/journal.pone.0162642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330453/
https://www.ncbi.nlm.nih.gov/pubmed/28245241
http://dx.doi.org/10.1371/journal.pone.0162642

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