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Design of T cell receptor libraries with diverse binding properties to examine adoptive T cell responses

Adoptive T cell therapies have shown significant promise in the treatment of cancer and viral diseases. One approach, that introduces antigen-specific T cell receptors (TCRs) into ex vivo activated T cells, is designed to overcome central tolerance mechanisms that prevent responses by endogenous T c...

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Detalles Bibliográficos
Autores principales:	Chervin, A.S., Stone, J.D., Soto, C.M., Engels, B., Schreiber, H., Roy, E.J., Kranz, D.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330764/ https://www.ncbi.nlm.nih.gov/pubmed/23052828 http://dx.doi.org/10.1038/gt.2012.80

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