Early human embryos are naturally aneuploid—can that be corrected?

Aneuploidy is common and may be a natural occurrence in early human embryos. Selecting against embryos containing aneuploid cells for embryo transfer has been reported to increase clinical pregnancies per transfer in some studies, but not others. Some aneuploidy is due to misallocation of chromosome...

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Detalles Bibliográficos
Autores principales: Lee, Amy, Kiessling, Ann A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330987/
https://www.ncbi.nlm.nih.gov/pubmed/27900612
http://dx.doi.org/10.1007/s10815-016-0845-7
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author Lee, Amy
Kiessling, Ann A.
author_facet Lee, Amy
Kiessling, Ann A.
author_sort Lee, Amy
collection PubMed
description Aneuploidy is common and may be a natural occurrence in early human embryos. Selecting against embryos containing aneuploid cells for embryo transfer has been reported to increase clinical pregnancies per transfer in some studies, but not others. Some aneuploidy is due to misallocation of chromosomes during meiosis, in either the egg or sperm, but most aneuploidy is due to misallocation of chromosomes during mitoses after fertilization. Big questions are as follows: Why does this happen? How much aneuploidy in a preimplantation embryo is compatible with normal fetal development? Is aneuploidy increased by in vitro culture, and/or could it be prevented or corrected in the IVF lab?
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spelling pubmed-53309872017-03-01 Early human embryos are naturally aneuploid—can that be corrected? Lee, Amy Kiessling, Ann A. J Assist Reprod Genet Review Aneuploidy is common and may be a natural occurrence in early human embryos. Selecting against embryos containing aneuploid cells for embryo transfer has been reported to increase clinical pregnancies per transfer in some studies, but not others. Some aneuploidy is due to misallocation of chromosomes during meiosis, in either the egg or sperm, but most aneuploidy is due to misallocation of chromosomes during mitoses after fertilization. Big questions are as follows: Why does this happen? How much aneuploidy in a preimplantation embryo is compatible with normal fetal development? Is aneuploidy increased by in vitro culture, and/or could it be prevented or corrected in the IVF lab? Springer US 2016-11-29 2017-01 /pmc/articles/PMC5330987/ /pubmed/27900612 http://dx.doi.org/10.1007/s10815-016-0845-7 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Lee, Amy
Kiessling, Ann A.
Early human embryos are naturally aneuploid—can that be corrected?
title Early human embryos are naturally aneuploid—can that be corrected?
title_full Early human embryos are naturally aneuploid—can that be corrected?
title_fullStr Early human embryos are naturally aneuploid—can that be corrected?
title_full_unstemmed Early human embryos are naturally aneuploid—can that be corrected?
title_short Early human embryos are naturally aneuploid—can that be corrected?
title_sort early human embryos are naturally aneuploid—can that be corrected?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330987/
https://www.ncbi.nlm.nih.gov/pubmed/27900612
http://dx.doi.org/10.1007/s10815-016-0845-7
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