A Genetic Screen Reveals Novel Targets to Render Pseudomonas aeruginosa Sensitive to Lysozyme and Cell Wall-Targeting Antibiotics

Pseudomonas aeruginosa is capable of establishing airway infections. Human airway mucus contains a large amount of lysozyme, which hydrolyzes bacterial cell walls. P. aeruginosa, however, is known to be resistant to lysozyme. Here, we performed a genetic screen using a mutant library of PAO1, a prot...

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Detalles Bibliográficos
Autores principales: Lee, Kang-Mu, Lee, Keehoon, Go, Junhyeok, Park, In Ho, Shin, Jeon-Soo, Choi, Jae Young, Kim, Hyun Jik, Yoon, Sang Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331053/
https://www.ncbi.nlm.nih.gov/pubmed/28299285
http://dx.doi.org/10.3389/fcimb.2017.00059

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