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Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis

Age-related macular degeneration (ARMD) is the leading cause of vision loss in developed countries. Hallmarks of the disease are well known; indeed, this pathology is characterized by lipofuscin accumulation, is principally composed of lipid-containing residues of lysosomal digestion. The N-retinyl-...

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Detalles Bibliográficos
Autores principales:	Balmer, Delphine, Bapst-Wicht, Linda, Pyakurel, Aswin, Emery, Martine, Nanchen, Natacha, Bochet, Christian G., Roduit, Raphael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331064/ https://www.ncbi.nlm.nih.gov/pubmed/28298893 http://dx.doi.org/10.3389/fnagi.2017.00043

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