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Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course

Surgical closure of the ventricular septal defect is the most commonly performed procedure in pediatric cardiac surgery. There are conflicting data on weight at operation as risk factor for a complicated course. We performed a retrospective evaluation of mortality and morbidity in all patients under...

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Autores principales: Schipper, Maartje, Slieker, Martijn G., Schoof, Paul H., Breur, Johannes M. P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331080/
https://www.ncbi.nlm.nih.gov/pubmed/27872996
http://dx.doi.org/10.1007/s00246-016-1508-2
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author Schipper, Maartje
Slieker, Martijn G.
Schoof, Paul H.
Breur, Johannes M. P. J.
author_facet Schipper, Maartje
Slieker, Martijn G.
Schoof, Paul H.
Breur, Johannes M. P. J.
author_sort Schipper, Maartje
collection PubMed
description Surgical closure of the ventricular septal defect is the most commonly performed procedure in pediatric cardiac surgery. There are conflicting data on weight at operation as risk factor for a complicated course. We performed a retrospective evaluation of mortality and morbidity in all patients undergoing surgical ventricular septal defect closure at our institution between 2004 and 2012 to identify risk factor for a complicated course. Multivariate logistic regression modeling was performed to identify risk factors for a complicated course. 243 patients who underwent surgical ventricular septal defect closure were included. Median age at operation was 168.0 days (range 17–6898), the median weight 6.0 kg (range 2.1–102.0). No deaths occurred. Two patients (0.8%) required a pacemaker for permanent heart block. Five patients (2.1%) underwent reoperation for a hemodynamically important residual ventricular septal defect. No other major adverse events occurred. No risk factors for major adverse events could be established. Multivariate analysis identified a genetic syndrome, long bypass time and low weight at operation as independent risk factors for a prolonged intensive care stay (>1 day) and prolonged ventilation time (>6 h). Contemporary results of surgical VSD closure are excellent with no mortality and low morbidity in this series. Although it is associated with increased ventilation time and a longer hospital stay, low bodyweight at operation is not associated with an increased risk of complications or major adverse events in our series.
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spelling pubmed-53310802017-03-13 Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course Schipper, Maartje Slieker, Martijn G. Schoof, Paul H. Breur, Johannes M. P. J. Pediatr Cardiol Original Article Surgical closure of the ventricular septal defect is the most commonly performed procedure in pediatric cardiac surgery. There are conflicting data on weight at operation as risk factor for a complicated course. We performed a retrospective evaluation of mortality and morbidity in all patients undergoing surgical ventricular septal defect closure at our institution between 2004 and 2012 to identify risk factor for a complicated course. Multivariate logistic regression modeling was performed to identify risk factors for a complicated course. 243 patients who underwent surgical ventricular septal defect closure were included. Median age at operation was 168.0 days (range 17–6898), the median weight 6.0 kg (range 2.1–102.0). No deaths occurred. Two patients (0.8%) required a pacemaker for permanent heart block. Five patients (2.1%) underwent reoperation for a hemodynamically important residual ventricular septal defect. No other major adverse events occurred. No risk factors for major adverse events could be established. Multivariate analysis identified a genetic syndrome, long bypass time and low weight at operation as independent risk factors for a prolonged intensive care stay (>1 day) and prolonged ventilation time (>6 h). Contemporary results of surgical VSD closure are excellent with no mortality and low morbidity in this series. Although it is associated with increased ventilation time and a longer hospital stay, low bodyweight at operation is not associated with an increased risk of complications or major adverse events in our series. Springer US 2016-11-21 2017 /pmc/articles/PMC5331080/ /pubmed/27872996 http://dx.doi.org/10.1007/s00246-016-1508-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Schipper, Maartje
Slieker, Martijn G.
Schoof, Paul H.
Breur, Johannes M. P. J.
Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title_full Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title_fullStr Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title_full_unstemmed Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title_short Surgical Repair of Ventricular Septal Defect; Contemporary Results and Risk Factors for a Complicated Course
title_sort surgical repair of ventricular septal defect; contemporary results and risk factors for a complicated course
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331080/
https://www.ncbi.nlm.nih.gov/pubmed/27872996
http://dx.doi.org/10.1007/s00246-016-1508-2
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