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Sensing infection and tissue damage

Innate and adaptive immunity work concertedly in vertebrates to restore homoeostasis following pathogen invasion or other insults. Like all homoeostatic circuits, immunity relies on an integrated system of sensors, transducers and effectors that can be analysed in cellular or molecular terms. At the...

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Autor principal: Reis e Sousa, Caetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331196/
https://www.ncbi.nlm.nih.gov/pubmed/28119319
http://dx.doi.org/10.15252/emmm.201607227
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author Reis e Sousa, Caetano
author_facet Reis e Sousa, Caetano
author_sort Reis e Sousa, Caetano
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description Innate and adaptive immunity work concertedly in vertebrates to restore homoeostasis following pathogen invasion or other insults. Like all homoeostatic circuits, immunity relies on an integrated system of sensors, transducers and effectors that can be analysed in cellular or molecular terms. At the cellular level, T and B lymphocytes act as an effector arm of immunity that is mobilised in response to signals transduced by innate immune cells that detect a given insult. These innate cells are spread around the body and include dendritic cells (DCs), the chief immune sensors of pathogen invasion and tumour growth. At the molecular level, DCs possess receptors that directly sense pathogen presence and tissue damage and that signal via transduction pathways to control antigen presentation or regulate a plethora of genes encoding effector proteins that regulate immunity. Notably, molecular circuits for pathogen detection are not confined to DCs or even to immune cells. All cells express sensors and transducers that monitor invasion by viruses and bacteria and elicit suitable effector barriers to pathogen propagation. Here, I discuss work from my laboratory that has contributed to our understanding of these issues over the years.
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spelling pubmed-53311962017-03-06 Sensing infection and tissue damage Reis e Sousa, Caetano EMBO Mol Med Louis‐Jeantet Prize Winner: Commentary Innate and adaptive immunity work concertedly in vertebrates to restore homoeostasis following pathogen invasion or other insults. Like all homoeostatic circuits, immunity relies on an integrated system of sensors, transducers and effectors that can be analysed in cellular or molecular terms. At the cellular level, T and B lymphocytes act as an effector arm of immunity that is mobilised in response to signals transduced by innate immune cells that detect a given insult. These innate cells are spread around the body and include dendritic cells (DCs), the chief immune sensors of pathogen invasion and tumour growth. At the molecular level, DCs possess receptors that directly sense pathogen presence and tissue damage and that signal via transduction pathways to control antigen presentation or regulate a plethora of genes encoding effector proteins that regulate immunity. Notably, molecular circuits for pathogen detection are not confined to DCs or even to immune cells. All cells express sensors and transducers that monitor invasion by viruses and bacteria and elicit suitable effector barriers to pathogen propagation. Here, I discuss work from my laboratory that has contributed to our understanding of these issues over the years. John Wiley and Sons Inc. 2017-01-24 2017-03 /pmc/articles/PMC5331196/ /pubmed/28119319 http://dx.doi.org/10.15252/emmm.201607227 Text en © 2017 The Author. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Louis‐Jeantet Prize Winner: Commentary
Reis e Sousa, Caetano
Sensing infection and tissue damage
title Sensing infection and tissue damage
title_full Sensing infection and tissue damage
title_fullStr Sensing infection and tissue damage
title_full_unstemmed Sensing infection and tissue damage
title_short Sensing infection and tissue damage
title_sort sensing infection and tissue damage
topic Louis‐Jeantet Prize Winner: Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331196/
https://www.ncbi.nlm.nih.gov/pubmed/28119319
http://dx.doi.org/10.15252/emmm.201607227
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