Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in‐depth characterization. Using a pipeline designed to suppress stroma‐derived signal, we find...

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Detalles Bibliográficos
Autores principales: Picco, Gabriele, Petti, Consalvo, Centonze, Alessia, Torchiaro, Erica, Crisafulli, Giovanni, Novara, Luca, Acquaviva, Andrea, Bardelli, Alberto, Medico, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331210/
https://www.ncbi.nlm.nih.gov/pubmed/28100566
http://dx.doi.org/10.15252/emmm.201606773

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