Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

The human RIF1 protein controls DNA replication, but the molecular mechanism is largely unknown. Here, we demonstrate that human RIF1 negatively regulates DNA replication by forming a complex with protein phosphatase 1 (PP1) that limits phosphorylation‐mediated activation of the MCM replicative heli...

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Detalles Bibliográficos
Autores principales: Hiraga, Shin‐ichiro, Ly, Tony, Garzón, Javier, Hořejší, Zuzana, Ohkubo, Yoshi‐nobu, Endo, Akinori, Obuse, Chikashi, Boulton, Simon J, Lamond, Angus I, Donaldson, Anne D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331243/
https://www.ncbi.nlm.nih.gov/pubmed/28077461
http://dx.doi.org/10.15252/embr.201641983

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