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Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score

OBJECTIVE: Although various risk stratification models are available and currently being used, the performance of these models in different populations is still controversial. We aimed to investigate the relation between the Framingham and SCORE models and the presence and severity of coronary arter...

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Autores principales: Günaydın, Zeki Yüksel, Karagöz, Ahmet, Bektaş, Osman, Kaya, Ahmet, Kırış, Tuncay, Erdoğan, Güney, Işık, Turgay, Ayhan, Erkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331373/
https://www.ncbi.nlm.nih.gov/pubmed/26680546
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6317
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author Günaydın, Zeki Yüksel
Karagöz, Ahmet
Bektaş, Osman
Kaya, Ahmet
Kırış, Tuncay
Erdoğan, Güney
Işık, Turgay
Ayhan, Erkan
author_facet Günaydın, Zeki Yüksel
Karagöz, Ahmet
Bektaş, Osman
Kaya, Ahmet
Kırış, Tuncay
Erdoğan, Güney
Işık, Turgay
Ayhan, Erkan
author_sort Günaydın, Zeki Yüksel
collection PubMed
description OBJECTIVE: Although various risk stratification models are available and currently being used, the performance of these models in different populations is still controversial. We aimed to investigate the relation between the Framingham and SCORE models and the presence and severity of coronary artery disease, which is detected using the SYNTAX score. METHODS: The observational cross-sectional study population consisted of 227 patients with a mean age of 63.3±9.2 years. The patients were classified into low- and high-risk groups in the Framingham and SCORE models separately. Following coronary angiography, the patients were classified into SYNTAX=0 (SYNTAX score 0), low SYNTAX (SYNTAX score 1–22), and high SYNTAX (SYNTAX score>22) groups. The relation between the risk models and SYNTAX score was evaluated by student t test, Mann–Whitney U test or Kruskal–Wallis test and Receiver operating characteristic analysis were used to detect the discrimination ability in the prediction of SYNTAX score>0 and a high SYNTAX score. RESULTS: Both the Framingham and SCORE models were found to be effective in predicting the presence of coronary artery disease, and neither of the two models had superiority over each other [AUC=0.819 (0.767, 0.871) vs. 0.811 (0.757, 0.861), p=0.881]. Furthermore, both models were also effective in predicting the extent and severity of coronary artery disease [AUC=0.724 (0.656, 0.798) vs. 0.730 (0.662, 0.802), p=0.224]. When the subgroups were analyzed, the SCORE model was found to be better in predicting coronary artery disease extent and severity in subgroups of men and diabetics {[AUC=0.737 (0.668, 0.844) vs. 0.665 (0.560, 0.790), p=0.019], [AUC=0.733 (0.684, 0.798) vs. 0.680 (0.654, 0.750) p=0.029], respectively). CONCLUSION: In addition to their role in predicting cardiovascular events, the use of the Framingham and SCORE models may also have utility in predicting the extent and severity of coronary artery disease. The SCORE risk model has a slightly better performance than the Framingham risk model.
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spelling pubmed-53313732017-06-28 Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score Günaydın, Zeki Yüksel Karagöz, Ahmet Bektaş, Osman Kaya, Ahmet Kırış, Tuncay Erdoğan, Güney Işık, Turgay Ayhan, Erkan Anatol J Cardiol Original Investigation OBJECTIVE: Although various risk stratification models are available and currently being used, the performance of these models in different populations is still controversial. We aimed to investigate the relation between the Framingham and SCORE models and the presence and severity of coronary artery disease, which is detected using the SYNTAX score. METHODS: The observational cross-sectional study population consisted of 227 patients with a mean age of 63.3±9.2 years. The patients were classified into low- and high-risk groups in the Framingham and SCORE models separately. Following coronary angiography, the patients were classified into SYNTAX=0 (SYNTAX score 0), low SYNTAX (SYNTAX score 1–22), and high SYNTAX (SYNTAX score>22) groups. The relation between the risk models and SYNTAX score was evaluated by student t test, Mann–Whitney U test or Kruskal–Wallis test and Receiver operating characteristic analysis were used to detect the discrimination ability in the prediction of SYNTAX score>0 and a high SYNTAX score. RESULTS: Both the Framingham and SCORE models were found to be effective in predicting the presence of coronary artery disease, and neither of the two models had superiority over each other [AUC=0.819 (0.767, 0.871) vs. 0.811 (0.757, 0.861), p=0.881]. Furthermore, both models were also effective in predicting the extent and severity of coronary artery disease [AUC=0.724 (0.656, 0.798) vs. 0.730 (0.662, 0.802), p=0.224]. When the subgroups were analyzed, the SCORE model was found to be better in predicting coronary artery disease extent and severity in subgroups of men and diabetics {[AUC=0.737 (0.668, 0.844) vs. 0.665 (0.560, 0.790), p=0.019], [AUC=0.733 (0.684, 0.798) vs. 0.680 (0.654, 0.750) p=0.029], respectively). CONCLUSION: In addition to their role in predicting cardiovascular events, the use of the Framingham and SCORE models may also have utility in predicting the extent and severity of coronary artery disease. The SCORE risk model has a slightly better performance than the Framingham risk model. Kare Publishing 2016-06 2015-06-30 /pmc/articles/PMC5331373/ /pubmed/26680546 http://dx.doi.org/10.5152/AnatolJCardiol.2015.6317 Text en Copyright © 2016 Turkish Society of Cardiology http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Investigation
Günaydın, Zeki Yüksel
Karagöz, Ahmet
Bektaş, Osman
Kaya, Ahmet
Kırış, Tuncay
Erdoğan, Güney
Işık, Turgay
Ayhan, Erkan
Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title_full Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title_fullStr Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title_full_unstemmed Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title_short Comparison of the Framingham risk and SCORE models in predicting the presence and severity of coronary artery disease considering SYNTAX score
title_sort comparison of the framingham risk and score models in predicting the presence and severity of coronary artery disease considering syntax score
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331373/
https://www.ncbi.nlm.nih.gov/pubmed/26680546
http://dx.doi.org/10.5152/AnatolJCardiol.2015.6317
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