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Combined Ligand/Structure-Based Virtual Screening and Molecular Dynamics Simulations of Steroidal Androgen Receptor Antagonists

The antiandrogens, such as bicalutamide, targeting the androgen receptor (AR), are the main endocrine therapies for prostate cancer (PCa). But as drug resistance to antiandrogens emerges in advanced PCa, there presents a high medical need for exploitation of novel AR antagonists. In this work, the r...

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Detalles Bibliográficos
Autores principales:	Wang, Yuwei, Han, Rui, Zhang, Huimin, Liu, Hongli, Li, Jiazhong, Liu, Huanxiang, Gramatica, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331419/ https://www.ncbi.nlm.nih.gov/pubmed/28293633 http://dx.doi.org/10.1155/2017/3572394

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