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Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini

[Image: see text] Light-chain (AL)-associated amyloidosis is a systemic disorder involving the formation and deposition of immunoglobulin AL fibrils in various bodily organs. One severe instance of AL disease is exhibited by the patient-derived variable domain (V(L)) of the light chain AL-09, a 108...

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Detalles Bibliográficos
Autores principales:	Piehl, Dennis W., Blancas-Mejía, Luis M., Wall, Jonathan S., Kennel, Stephen J., Ramirez-Alvarado, Marina, Rienstra, Chad M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331457/ https://www.ncbi.nlm.nih.gov/pubmed/28261692 http://dx.doi.org/10.1021/acsomega.6b00494

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