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Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD)
As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is rel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331527/ https://www.ncbi.nlm.nih.gov/pubmed/28146130 http://dx.doi.org/10.3390/nu9020096 |
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author | Chen, Qian Wang, Tingting Li, Jian Wang, Sijian Qiu, Feng Yu, Haiyang Zhang, Yi Wang, Tao |
author_facet | Chen, Qian Wang, Tingting Li, Jian Wang, Sijian Qiu, Feng Yu, Haiyang Zhang, Yi Wang, Tao |
author_sort | Chen, Qian |
collection | PubMed |
description | As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pathological processes, including: (1) augmenting lipogenesis; (2) leading to mitochondrial dysfunction; (3) stimulating the activation of inflammatory pathways; and (4) causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXR)α, sterol regulatory element binding protein (SREBP)-1/1c, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), peroxisome proliferator–activated receptor α (PPARα), leptin nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), c-Jun amino terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3K) and adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK). Until now, a series of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the natural products (e.g., curcumin, resveratrol, and (−)-epicatechin) and their mechanisms of ameliorating fructose-induced NAFLD over the past years. Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD. |
format | Online Article Text |
id | pubmed-5331527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53315272017-03-13 Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) Chen, Qian Wang, Tingting Li, Jian Wang, Sijian Qiu, Feng Yu, Haiyang Zhang, Yi Wang, Tao Nutrients Review As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pathological processes, including: (1) augmenting lipogenesis; (2) leading to mitochondrial dysfunction; (3) stimulating the activation of inflammatory pathways; and (4) causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXR)α, sterol regulatory element binding protein (SREBP)-1/1c, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), peroxisome proliferator–activated receptor α (PPARα), leptin nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), c-Jun amino terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3K) and adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK). Until now, a series of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the natural products (e.g., curcumin, resveratrol, and (−)-epicatechin) and their mechanisms of ameliorating fructose-induced NAFLD over the past years. Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD. MDPI 2017-01-31 /pmc/articles/PMC5331527/ /pubmed/28146130 http://dx.doi.org/10.3390/nu9020096 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Qian Wang, Tingting Li, Jian Wang, Sijian Qiu, Feng Yu, Haiyang Zhang, Yi Wang, Tao Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title_full | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title_fullStr | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title_full_unstemmed | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title_short | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) |
title_sort | effects of natural products on fructose-induced nonalcoholic fatty liver disease (nafld) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331527/ https://www.ncbi.nlm.nih.gov/pubmed/28146130 http://dx.doi.org/10.3390/nu9020096 |
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