Cargando…
Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers
Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331541/ https://www.ncbi.nlm.nih.gov/pubmed/28165405 http://dx.doi.org/10.3390/nu9020110 |
_version_ | 1782511397300600832 |
---|---|
author | Badeau, Robert M. Honka, Miikka-Juhani Bucci, Marco Iozzo, Patricia Eriksson, Johan G. Nuutila, Pirjo |
author_facet | Badeau, Robert M. Honka, Miikka-Juhani Bucci, Marco Iozzo, Patricia Eriksson, Johan G. Nuutila, Pirjo |
author_sort | Badeau, Robert M. |
collection | PubMed |
description | Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance. Methods: Thirty-seven elderly women were separated into elderly offspring from obese mothers (OOM; n = 17) and elderly offspring from lean/normal weight mothers (OLM; n = 20) groups. We measured plasma metabolites using proton nuclear magnetic resonance ((1)H-NMR) and insulin-dependent tissue-specific glucose uptake in skeletal muscle was assessed. Associations were made between metabolites and glucose uptake. Results: Compared to the OLM group, we found that the docosahexaenoic acid percentage of the total long-chain n-3 fatty acids (DHA/FA) was significantly lower in OOM (p = 0.015). DHA/FA associated significantly with skeletal muscle glucose uptake (GU) (p = 0.031) and the metabolizable glucose value derived from hyperinsulinemic-euglycemic clamp technique (M-value) in the OLM group only (p = 0.050). Conclusions: DHA/FA is associated with insulin-dependent skeletal muscle glucose uptake and this association is significantly weakened in the offspring of obese mothers. |
format | Online Article Text |
id | pubmed-5331541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53315412017-03-13 Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers Badeau, Robert M. Honka, Miikka-Juhani Bucci, Marco Iozzo, Patricia Eriksson, Johan G. Nuutila, Pirjo Nutrients Article Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance. Methods: Thirty-seven elderly women were separated into elderly offspring from obese mothers (OOM; n = 17) and elderly offspring from lean/normal weight mothers (OLM; n = 20) groups. We measured plasma metabolites using proton nuclear magnetic resonance ((1)H-NMR) and insulin-dependent tissue-specific glucose uptake in skeletal muscle was assessed. Associations were made between metabolites and glucose uptake. Results: Compared to the OLM group, we found that the docosahexaenoic acid percentage of the total long-chain n-3 fatty acids (DHA/FA) was significantly lower in OOM (p = 0.015). DHA/FA associated significantly with skeletal muscle glucose uptake (GU) (p = 0.031) and the metabolizable glucose value derived from hyperinsulinemic-euglycemic clamp technique (M-value) in the OLM group only (p = 0.050). Conclusions: DHA/FA is associated with insulin-dependent skeletal muscle glucose uptake and this association is significantly weakened in the offspring of obese mothers. MDPI 2017-02-04 /pmc/articles/PMC5331541/ /pubmed/28165405 http://dx.doi.org/10.3390/nu9020110 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Badeau, Robert M. Honka, Miikka-Juhani Bucci, Marco Iozzo, Patricia Eriksson, Johan G. Nuutila, Pirjo Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title | Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title_full | Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title_fullStr | Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title_full_unstemmed | Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title_short | Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers |
title_sort | circulating docosahexaenoic acid associates with insulin-dependent skeletal muscle and whole body glucose uptake in older women born from normal weight mothers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331541/ https://www.ncbi.nlm.nih.gov/pubmed/28165405 http://dx.doi.org/10.3390/nu9020110 |
work_keys_str_mv | AT badeaurobertm circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers AT honkamiikkajuhani circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers AT buccimarco circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers AT iozzopatricia circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers AT erikssonjohang circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers AT nuutilapirjo circulatingdocosahexaenoicacidassociateswithinsulindependentskeletalmuscleandwholebodyglucoseuptakeinolderwomenbornfromnormalweightmothers |