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Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis

Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin...

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Autores principales: Cañete, Ana, Cano, Elena, Muñoz-Chápuli, Ramón, Carmona, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331590/
https://www.ncbi.nlm.nih.gov/pubmed/28230720
http://dx.doi.org/10.3390/nu9020159
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author Cañete, Ana
Cano, Elena
Muñoz-Chápuli, Ramón
Carmona, Rita
author_facet Cañete, Ana
Cano, Elena
Muñoz-Chápuli, Ramón
Carmona, Rita
author_sort Cañete, Ana
collection PubMed
description Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system.
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spelling pubmed-53315902017-03-13 Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis Cañete, Ana Cano, Elena Muñoz-Chápuli, Ramón Carmona, Rita Nutrients Review Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system. MDPI 2017-02-20 /pmc/articles/PMC5331590/ /pubmed/28230720 http://dx.doi.org/10.3390/nu9020159 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cañete, Ana
Cano, Elena
Muñoz-Chápuli, Ramón
Carmona, Rita
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title_full Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title_fullStr Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title_full_unstemmed Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title_short Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
title_sort role of vitamin a/retinoic acid in regulation of embryonic and adult hematopoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331590/
https://www.ncbi.nlm.nih.gov/pubmed/28230720
http://dx.doi.org/10.3390/nu9020159
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