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Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331590/ https://www.ncbi.nlm.nih.gov/pubmed/28230720 http://dx.doi.org/10.3390/nu9020159 |
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author | Cañete, Ana Cano, Elena Muñoz-Chápuli, Ramón Carmona, Rita |
author_facet | Cañete, Ana Cano, Elena Muñoz-Chápuli, Ramón Carmona, Rita |
author_sort | Cañete, Ana |
collection | PubMed |
description | Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system. |
format | Online Article Text |
id | pubmed-5331590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53315902017-03-13 Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis Cañete, Ana Cano, Elena Muñoz-Chápuli, Ramón Carmona, Rita Nutrients Review Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system. MDPI 2017-02-20 /pmc/articles/PMC5331590/ /pubmed/28230720 http://dx.doi.org/10.3390/nu9020159 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cañete, Ana Cano, Elena Muñoz-Chápuli, Ramón Carmona, Rita Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title_full | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title_fullStr | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title_full_unstemmed | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title_short | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
title_sort | role of vitamin a/retinoic acid in regulation of embryonic and adult hematopoiesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331590/ https://www.ncbi.nlm.nih.gov/pubmed/28230720 http://dx.doi.org/10.3390/nu9020159 |
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