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‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants

In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this g...

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Autores principales: Lopez-Teros, Veronica, Limon-Miro, Ana Teresa, Astiazaran-Garcia, Humberto, Tanumihardjo, Sherry A., Tortoledo-Ortiz, Orlando, Valencia, Mauro E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331600/
https://www.ncbi.nlm.nih.gov/pubmed/28230781
http://dx.doi.org/10.3390/nu9020169
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author Lopez-Teros, Veronica
Limon-Miro, Ana Teresa
Astiazaran-Garcia, Humberto
Tanumihardjo, Sherry A.
Tortoledo-Ortiz, Orlando
Valencia, Mauro E.
author_facet Lopez-Teros, Veronica
Limon-Miro, Ana Teresa
Astiazaran-Garcia, Humberto
Tanumihardjo, Sherry A.
Tortoledo-Ortiz, Orlando
Valencia, Mauro E.
author_sort Lopez-Teros, Veronica
collection PubMed
description In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this group. We combined the assessment of VA status in lactating women using BM retinol and a stable isotope ‘dose-to-mother’ technique to measure BM production in women from urban and agricultural areas. Infants’ mean BM intake was 758 ± 185 mL, and no difference was observed between both areas (p = 0.067). Mean BM retinol concentration was 1.09 μmol/L, which was significantly lower for the agricultural area (p = 0.028). Based on BM retinol concentration, 57% of women were VAD; although this prevalence fell to 16% when based on fat content. Regardless of the VA biomarker used here, infants from the urban and agricultural areas cover only 66% and 49% of their dietary adequate intake from BM, respectively (p = 0.054). Our data indicate that VAD is still a public health concern in Mexico. Adopting both methods to assess VA transfer from the mother to the breastfed child offers an innovative approach towards the nutritional assessment of vulnerable groups.
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spelling pubmed-53316002017-03-13 ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants Lopez-Teros, Veronica Limon-Miro, Ana Teresa Astiazaran-Garcia, Humberto Tanumihardjo, Sherry A. Tortoledo-Ortiz, Orlando Valencia, Mauro E. Nutrients Article In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this group. We combined the assessment of VA status in lactating women using BM retinol and a stable isotope ‘dose-to-mother’ technique to measure BM production in women from urban and agricultural areas. Infants’ mean BM intake was 758 ± 185 mL, and no difference was observed between both areas (p = 0.067). Mean BM retinol concentration was 1.09 μmol/L, which was significantly lower for the agricultural area (p = 0.028). Based on BM retinol concentration, 57% of women were VAD; although this prevalence fell to 16% when based on fat content. Regardless of the VA biomarker used here, infants from the urban and agricultural areas cover only 66% and 49% of their dietary adequate intake from BM, respectively (p = 0.054). Our data indicate that VAD is still a public health concern in Mexico. Adopting both methods to assess VA transfer from the mother to the breastfed child offers an innovative approach towards the nutritional assessment of vulnerable groups. MDPI 2017-02-21 /pmc/articles/PMC5331600/ /pubmed/28230781 http://dx.doi.org/10.3390/nu9020169 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lopez-Teros, Veronica
Limon-Miro, Ana Teresa
Astiazaran-Garcia, Humberto
Tanumihardjo, Sherry A.
Tortoledo-Ortiz, Orlando
Valencia, Mauro E.
‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title_full ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title_fullStr ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title_full_unstemmed ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title_short ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
title_sort ‘dose-to-mother’ deuterium oxide dilution technique: an accurate strategy to measure vitamin a intake in breastfed infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331600/
https://www.ncbi.nlm.nih.gov/pubmed/28230781
http://dx.doi.org/10.3390/nu9020169
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