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‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants
In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this g...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331600/ https://www.ncbi.nlm.nih.gov/pubmed/28230781 http://dx.doi.org/10.3390/nu9020169 |
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author | Lopez-Teros, Veronica Limon-Miro, Ana Teresa Astiazaran-Garcia, Humberto Tanumihardjo, Sherry A. Tortoledo-Ortiz, Orlando Valencia, Mauro E. |
author_facet | Lopez-Teros, Veronica Limon-Miro, Ana Teresa Astiazaran-Garcia, Humberto Tanumihardjo, Sherry A. Tortoledo-Ortiz, Orlando Valencia, Mauro E. |
author_sort | Lopez-Teros, Veronica |
collection | PubMed |
description | In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this group. We combined the assessment of VA status in lactating women using BM retinol and a stable isotope ‘dose-to-mother’ technique to measure BM production in women from urban and agricultural areas. Infants’ mean BM intake was 758 ± 185 mL, and no difference was observed between both areas (p = 0.067). Mean BM retinol concentration was 1.09 μmol/L, which was significantly lower for the agricultural area (p = 0.028). Based on BM retinol concentration, 57% of women were VAD; although this prevalence fell to 16% when based on fat content. Regardless of the VA biomarker used here, infants from the urban and agricultural areas cover only 66% and 49% of their dietary adequate intake from BM, respectively (p = 0.054). Our data indicate that VAD is still a public health concern in Mexico. Adopting both methods to assess VA transfer from the mother to the breastfed child offers an innovative approach towards the nutritional assessment of vulnerable groups. |
format | Online Article Text |
id | pubmed-5331600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53316002017-03-13 ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants Lopez-Teros, Veronica Limon-Miro, Ana Teresa Astiazaran-Garcia, Humberto Tanumihardjo, Sherry A. Tortoledo-Ortiz, Orlando Valencia, Mauro E. Nutrients Article In Mexico, infants (0–2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this group. We combined the assessment of VA status in lactating women using BM retinol and a stable isotope ‘dose-to-mother’ technique to measure BM production in women from urban and agricultural areas. Infants’ mean BM intake was 758 ± 185 mL, and no difference was observed between both areas (p = 0.067). Mean BM retinol concentration was 1.09 μmol/L, which was significantly lower for the agricultural area (p = 0.028). Based on BM retinol concentration, 57% of women were VAD; although this prevalence fell to 16% when based on fat content. Regardless of the VA biomarker used here, infants from the urban and agricultural areas cover only 66% and 49% of their dietary adequate intake from BM, respectively (p = 0.054). Our data indicate that VAD is still a public health concern in Mexico. Adopting both methods to assess VA transfer from the mother to the breastfed child offers an innovative approach towards the nutritional assessment of vulnerable groups. MDPI 2017-02-21 /pmc/articles/PMC5331600/ /pubmed/28230781 http://dx.doi.org/10.3390/nu9020169 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lopez-Teros, Veronica Limon-Miro, Ana Teresa Astiazaran-Garcia, Humberto Tanumihardjo, Sherry A. Tortoledo-Ortiz, Orlando Valencia, Mauro E. ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title | ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title_full | ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title_fullStr | ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title_full_unstemmed | ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title_short | ‘Dose-to-Mother’ Deuterium Oxide Dilution Technique: An Accurate Strategy to Measure Vitamin A Intake in Breastfed Infants |
title_sort | ‘dose-to-mother’ deuterium oxide dilution technique: an accurate strategy to measure vitamin a intake in breastfed infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331600/ https://www.ncbi.nlm.nih.gov/pubmed/28230781 http://dx.doi.org/10.3390/nu9020169 |
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