Cargando…
Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study
Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331606/ https://www.ncbi.nlm.nih.gov/pubmed/28241426 http://dx.doi.org/10.3390/nu9020175 |
_version_ | 1782511412381220864 |
---|---|
author | Freitas, Erika P. S. Cunha, Aline T. O. Aquino, Sephora L. S. Pedrosa, Lucia F. C. Lima, Severina C. V. C. Lima, Josivan G. Almeida, Maria G. Sena-Evangelista, Karine C. M. |
author_facet | Freitas, Erika P. S. Cunha, Aline T. O. Aquino, Sephora L. S. Pedrosa, Lucia F. C. Lima, Severina C. V. C. Lima, Josivan G. Almeida, Maria G. Sena-Evangelista, Karine C. M. |
author_sort | Freitas, Erika P. S. |
collection | PubMed |
description | Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0.001). Regression models indicated no significant differences in plasma zinc concentration (all p > 0.05) between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p < 0.001) independent from co-variable adjustments. Twenty-four hour urinary zinc excretion was significantly higher in the MS group (p = 0.008), and adjustments for age and sex explained 21% of the difference (R(2) = 0.21, p < 0.001). There were significant associations between zincuria and fasting blood glucose concentration (r = 0.479), waist circumference (r = 0.253), triglyceride concentration (r = 0.360), glycated hemoglobin concentration (r = 0.250), homeostatic model assessment—insulin resistance (r = 0.223), and high-sensitivity C-reactive protein concentration (r = 0.427) (all p < 0.05) in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria. |
format | Online Article Text |
id | pubmed-5331606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53316062017-03-13 Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study Freitas, Erika P. S. Cunha, Aline T. O. Aquino, Sephora L. S. Pedrosa, Lucia F. C. Lima, Severina C. V. C. Lima, Josivan G. Almeida, Maria G. Sena-Evangelista, Karine C. M. Nutrients Article Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0.001). Regression models indicated no significant differences in plasma zinc concentration (all p > 0.05) between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p < 0.001) independent from co-variable adjustments. Twenty-four hour urinary zinc excretion was significantly higher in the MS group (p = 0.008), and adjustments for age and sex explained 21% of the difference (R(2) = 0.21, p < 0.001). There were significant associations between zincuria and fasting blood glucose concentration (r = 0.479), waist circumference (r = 0.253), triglyceride concentration (r = 0.360), glycated hemoglobin concentration (r = 0.250), homeostatic model assessment—insulin resistance (r = 0.223), and high-sensitivity C-reactive protein concentration (r = 0.427) (all p < 0.05) in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria. MDPI 2017-02-22 /pmc/articles/PMC5331606/ /pubmed/28241426 http://dx.doi.org/10.3390/nu9020175 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Freitas, Erika P. S. Cunha, Aline T. O. Aquino, Sephora L. S. Pedrosa, Lucia F. C. Lima, Severina C. V. C. Lima, Josivan G. Almeida, Maria G. Sena-Evangelista, Karine C. M. Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title | Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title_full | Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title_fullStr | Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title_full_unstemmed | Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title_short | Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study |
title_sort | zinc status biomarkers and cardiometabolic risk factors in metabolic syndrome: a case control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331606/ https://www.ncbi.nlm.nih.gov/pubmed/28241426 http://dx.doi.org/10.3390/nu9020175 |
work_keys_str_mv | AT freitaserikaps zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT cunhaalineto zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT aquinosephorals zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT pedrosaluciafc zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT limaseverinacvc zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT limajosivang zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT almeidamariag zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy AT senaevangelistakarinecm zincstatusbiomarkersandcardiometabolicriskfactorsinmetabolicsyndromeacasecontrolstudy |