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Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice
The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, including cancers, in humans. On the other hand, animal studies by Dr. M. Waalkes’ group re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331735/ https://www.ncbi.nlm.nih.gov/pubmed/28265304 http://dx.doi.org/10.1186/s41021-016-0069-1 |
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author | Nohara, Keiko Suzuki, Takehiro Okamura, Kazuyuki Matsushita, Junya Takumi, Shota |
author_facet | Nohara, Keiko Suzuki, Takehiro Okamura, Kazuyuki Matsushita, Junya Takumi, Shota |
author_sort | Nohara, Keiko |
collection | PubMed |
description | The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, including cancers, in humans. On the other hand, animal studies by Dr. M. Waalkes’ group reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 (arsenite-F1) males of C3H mice, whose males tend to develop spontaneous hepatic tumors later in life. Since this mice model illuminated novel unidentified consequences of arsenic exposure, we wished to further investigate the background mechanisms. In the same experimental model, we identified a variety of factors that were affected by gestational arsenic exposure, including epigenetic and genetic changes, as possible constituents of multiple steps of late-onset hepatic tumor augmentation in arsenite-F1 males. Furthermore, our study discovered that the F2 males born to arsenite-F1 males developed hepatic tumors at a significantly higher rate than the control F2 males. The results imply that the tumor augmenting effect is inherited by arsenite-F2 males through the sperm of arsenite-F1. In this article, we summarized our studies on the consequences of gestational arsenite exposure in F1 and F2 mice to discuss novel aspects of biological effects of gestational arsenic exposure. |
format | Online Article Text |
id | pubmed-5331735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53317352017-03-06 Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice Nohara, Keiko Suzuki, Takehiro Okamura, Kazuyuki Matsushita, Junya Takumi, Shota Genes Environ Review The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, including cancers, in humans. On the other hand, animal studies by Dr. M. Waalkes’ group reported that arsenite exposure of pregnant F0 females, only from gestational day 8 to 18, increased hepatic tumors in the F1 (arsenite-F1) males of C3H mice, whose males tend to develop spontaneous hepatic tumors later in life. Since this mice model illuminated novel unidentified consequences of arsenic exposure, we wished to further investigate the background mechanisms. In the same experimental model, we identified a variety of factors that were affected by gestational arsenic exposure, including epigenetic and genetic changes, as possible constituents of multiple steps of late-onset hepatic tumor augmentation in arsenite-F1 males. Furthermore, our study discovered that the F2 males born to arsenite-F1 males developed hepatic tumors at a significantly higher rate than the control F2 males. The results imply that the tumor augmenting effect is inherited by arsenite-F2 males through the sperm of arsenite-F1. In this article, we summarized our studies on the consequences of gestational arsenite exposure in F1 and F2 mice to discuss novel aspects of biological effects of gestational arsenic exposure. BioMed Central 2017-03-01 /pmc/articles/PMC5331735/ /pubmed/28265304 http://dx.doi.org/10.1186/s41021-016-0069-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Nohara, Keiko Suzuki, Takehiro Okamura, Kazuyuki Matsushita, Junya Takumi, Shota Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title | Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title_full | Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title_fullStr | Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title_full_unstemmed | Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title_short | Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice |
title_sort | tumor-augmenting effects of gestational arsenic exposure on f1 and f2 in mice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331735/ https://www.ncbi.nlm.nih.gov/pubmed/28265304 http://dx.doi.org/10.1186/s41021-016-0069-1 |
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