The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important d...

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Autores principales: Zhou, Pingting, Li, Bo, Liu, Furao, Zhang, Meichao, Wang, Qian, Liu, Yuanhua, Yao, Yuan, Li, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331747/
https://www.ncbi.nlm.nih.gov/pubmed/28245823
http://dx.doi.org/10.1186/s12943-017-0624-9
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author Zhou, Pingting
Li, Bo
Liu, Furao
Zhang, Meichao
Wang, Qian
Liu, Yuanhua
Yao, Yuan
Li, Dong
author_facet Zhou, Pingting
Li, Bo
Liu, Furao
Zhang, Meichao
Wang, Qian
Liu, Yuanhua
Yao, Yuan
Li, Dong
author_sort Zhou, Pingting
collection PubMed
description The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.
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spelling pubmed-53317472017-03-06 The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer Zhou, Pingting Li, Bo Liu, Furao Zhang, Meichao Wang, Qian Liu, Yuanhua Yao, Yuan Li, Dong Mol Cancer Review The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy. BioMed Central 2017-02-28 /pmc/articles/PMC5331747/ /pubmed/28245823 http://dx.doi.org/10.1186/s12943-017-0624-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhou, Pingting
Li, Bo
Liu, Furao
Zhang, Meichao
Wang, Qian
Liu, Yuanhua
Yao, Yuan
Li, Dong
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title_full The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title_fullStr The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title_full_unstemmed The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title_short The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
title_sort epithelial to mesenchymal transition (emt) and cancer stem cells: implication for treatment resistance in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331747/
https://www.ncbi.nlm.nih.gov/pubmed/28245823
http://dx.doi.org/10.1186/s12943-017-0624-9
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