A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages

An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cyclins A, E, D1/D3 in macrophages, without evidence for D...

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Detalles Bibliográficos
Autores principales: Mlcochova, Petra, Sutherland, Katherine A, Watters, Sarah A, Bertoli, Cosetta, de Bruin, Rob AM, Rehwinkel, Jan, Neil, Stuart J, Lenzi, Gina M, Kim, Baek, Khwaja, Asim, Gage, Matthew C, Georgiou, Christiana, Chittka, Alexandra, Yona, Simon, Noursadeghi, Mahdad, Towers, Greg J, Gupta, Ravindra K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331754/
https://www.ncbi.nlm.nih.gov/pubmed/28122869
http://dx.doi.org/10.15252/embj.201696025

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