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Granulomatosis with polyangiitis involving the epiglottis

Granulomatosis with polyangiitis (GPA) frequently involves the upper respiratory tracts, but involvement of the epiglottis is extremely rare. This report describes a patient initially presenting with dysphagia and increasing stridor due to epiglottitis. Bronchoscopy showed swelling of the epiglottis...

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Autores principales: Aono, Yuya, Imokawa, Shiro, Uto, Tomohiro, Sato, Jun, Tanioka, Fumihiko, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331755/
https://www.ncbi.nlm.nih.gov/pubmed/28261483
http://dx.doi.org/10.1002/rcr2.226
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author Aono, Yuya
Imokawa, Shiro
Uto, Tomohiro
Sato, Jun
Tanioka, Fumihiko
Suda, Takafumi
author_facet Aono, Yuya
Imokawa, Shiro
Uto, Tomohiro
Sato, Jun
Tanioka, Fumihiko
Suda, Takafumi
author_sort Aono, Yuya
collection PubMed
description Granulomatosis with polyangiitis (GPA) frequently involves the upper respiratory tracts, but involvement of the epiglottis is extremely rare. This report describes a patient initially presenting with dysphagia and increasing stridor due to epiglottitis. Bronchoscopy showed swelling of the epiglottis with partly whitish nodular lesions, with biopsy specimens showing neutrophil infiltration and necrosis. Chest computed tomography showed multiple nodular consolidations in the bilateral lung parenchyma, and histological findings were consistent with vasculitis. The patient was diagnosed with GPA and responded well to treatment with prednisolone and cyclophosphamide. Although an uncommon manifestation, GPA should be included in the differential diagnosis of epiglottitis, especially in patients with lung parenchymal lesions suggestive of GPA.
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spelling pubmed-53317552017-03-03 Granulomatosis with polyangiitis involving the epiglottis Aono, Yuya Imokawa, Shiro Uto, Tomohiro Sato, Jun Tanioka, Fumihiko Suda, Takafumi Respirol Case Rep Case Reports Granulomatosis with polyangiitis (GPA) frequently involves the upper respiratory tracts, but involvement of the epiglottis is extremely rare. This report describes a patient initially presenting with dysphagia and increasing stridor due to epiglottitis. Bronchoscopy showed swelling of the epiglottis with partly whitish nodular lesions, with biopsy specimens showing neutrophil infiltration and necrosis. Chest computed tomography showed multiple nodular consolidations in the bilateral lung parenchyma, and histological findings were consistent with vasculitis. The patient was diagnosed with GPA and responded well to treatment with prednisolone and cyclophosphamide. Although an uncommon manifestation, GPA should be included in the differential diagnosis of epiglottitis, especially in patients with lung parenchymal lesions suggestive of GPA. John Wiley & Sons, Ltd 2017-03-01 /pmc/articles/PMC5331755/ /pubmed/28261483 http://dx.doi.org/10.1002/rcr2.226 Text en © 2017 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Aono, Yuya
Imokawa, Shiro
Uto, Tomohiro
Sato, Jun
Tanioka, Fumihiko
Suda, Takafumi
Granulomatosis with polyangiitis involving the epiglottis
title Granulomatosis with polyangiitis involving the epiglottis
title_full Granulomatosis with polyangiitis involving the epiglottis
title_fullStr Granulomatosis with polyangiitis involving the epiglottis
title_full_unstemmed Granulomatosis with polyangiitis involving the epiglottis
title_short Granulomatosis with polyangiitis involving the epiglottis
title_sort granulomatosis with polyangiitis involving the epiglottis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331755/
https://www.ncbi.nlm.nih.gov/pubmed/28261483
http://dx.doi.org/10.1002/rcr2.226
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