Cargando…

Conformational equilibria and intrinsic affinities define integrin activation

We show that the three conformational states of integrin α(5)β(1) have discrete free energies and define activation by measuring intrinsic affinities for ligand of each state and the equilibria linking them. The 5,000‐fold higher affinity of the extended‐open state than the bent‐closed and extended‐...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Su, Yang, Xia, Wei, Qin, Yan, Humphries, Martin J, Vestweber, Dietmar, Cabañas, Carlos, Lu, Chafen, Springer, Timothy A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331762/ https://www.ncbi.nlm.nih.gov/pubmed/28122868 http://dx.doi.org/10.15252/embj.201695803

Ejemplares similares

Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
por: Anderson, Jordan M., et al.
Publicado: (2022)

Binding Affinities Controlled by Shifting Conformational Equilibria: Opportunities and Limitations
por: Michielssens, Servaas, et al.
Publicado: (2015)

Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state
por: Li, Jing, et al.
Publicado: (2021)

Equilibria For Foil Focused Relativistic Electron Beams
por: Humphries, S
Publicado: (1983)

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
por: Luo, Bing-Hao, et al.
Publicado: (2004)

Exploring conformational equilibria of a heterodimeric ABC transporter
por: Timachi, M Hadi, et al.
Publicado: (2017)

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker
por: Bonazza, Klaus, et al.
Publicado: (2022)

Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery
por: Linclau, Bruno, et al.
Publicado: (2021)

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level
por: Sandal, Massimo, et al.
Publicado: (2008)

Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings
por: De Simone, Alfonso, et al.
Publicado: (2011)

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
por: Su, Yang, et al.
Publicado: (2022)

General structural features that regulate integrin affinity revealed by atypical αVβ8
por: Wang, Jianchuan, et al.
Publicado: (2019)

Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy
por: Moore, Travis I., et al.
Publicado: (2018)

Equilibria between the K(+) binding and cation vacancy conformations of potassium channels
por: He, Yao, et al.
Publicado: (2019)

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria
por: Elisi, Gian Marco, et al.
Publicado: (2020)

Measuring conformational equilibria in allosteric proteins with time-resolved tmFRET
por: Zagotta, William N., et al.
Publicado: (2023)

The primacy of affinity over clustering in regulation of adhesiveness of the integrin α(L)β(2)
por: Kim, Minsoo, et al.
Publicado: (2004)

Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state
por: Feng, Juan, et al.
Publicado: (2022)

Nash equilibria in human sensorimotor interactions explained by Q-learning with intrinsic costs
por: Lindig-León, Cecilia, et al.
Publicado: (2021)

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling
por: Robertson, Joseph, et al.
Publicado: (2015)

CHEMOTHERAPEUTIC EQUILIBRIA
por: Stearn, Allen E., et al.
Publicado: (1930)

Thermodynamic Equilibria and Extrema: Analysis of Attainability Regions and Partial Equilibria
por: Gorban, Alexander N, et al.
Publicado: (2006)

Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography
por: Girard, Eric, et al.
Publicado: (2022)

Mg(2+)-dependent conformational equilibria in CorA and an integrated view on transport regulation
por: Johansen, Nicolai Tidemand, et al.
Publicado: (2022)

Integrin intra-heterodimer affinity inversely correlates with integrin activatability
por: Sun, Guangyu, et al.
Publicado: (2021)

Prodomain–growth factor swapping in the structure of pro-TGF-β1
por: Zhao, Bo, et al.
Publicado: (2018)

Conformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation Equilibria
por: Kim, M. Olivia, et al.
Publicado: (2015)

Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup
por: Shin, Kyungsoo, et al.
Publicado: (2017)

On steady electromagnetic equilibria
por: Lehnert, B
Publicado: (1987)

Principles of phase equilibria
por: Wetmore, F E W, et al.
Publicado: (1951)

Alloy phase equilibria
por: Prince, A
Publicado: (1965)

Silicate melt equilibria
por: Eitel, Wilhelm
Publicado: (1951)

Phagocytic Integrins: Activation and Signaling
por: Torres-Gomez, Alvaro, et al.
Publicado: (2020)

Integrin Conformational Dynamics and Mechanotransduction
por: Kolasangiani, Reza, et al.
Publicado: (2022)

Dynamical selection of Nash equilibria using reinforcement learning: Emergence of heterogeneous mixed equilibria
por: Nicole, Robin, et al.
Publicado: (2018)

GARP regulates the bioavailability and activation of TGFβ
por: Wang, Rui, et al.
Publicado: (2012)

Chemokines and the Signaling Modules Regulating Integrin Affinity
por: Montresor, Alessio, et al.
Publicado: (2012)

Stability and perfection of nash equilibria
por: Damme, Eric
Publicado: (1991)

Phase equilibria in chemical engineering /
por: Walas, Stanley M.
Publicado: (1985)

Themodynamic equilibria of boiling mixtures
por: Hausen, H
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_ntn6vok0s4o48r08phfp0dscjk