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Gastric Cancer Genomics: Advances and Future Directions
Advancement in the field of cancer genomics is revolutionizing the molecular characterization of a wide variety of different cancers. Recent application of large-scale, next-generation sequencing technology to gastric cancer, which remains a major source of morbidity and mortality throughout the wor...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331775/ https://www.ncbi.nlm.nih.gov/pubmed/28275688 http://dx.doi.org/10.1016/j.jcmgh.2017.01.003 |
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author | Katona, Bryson W. Rustgi, Anil K. |
author_facet | Katona, Bryson W. Rustgi, Anil K. |
author_sort | Katona, Bryson W. |
collection | PubMed |
description | Advancement in the field of cancer genomics is revolutionizing the molecular characterization of a wide variety of different cancers. Recent application of large-scale, next-generation sequencing technology to gastric cancer, which remains a major source of morbidity and mortality throughout the world, has helped better define the complex genomic landscape of this cancer. These studies also have led to the development of novel genomically based molecular classification systems for gastric cancer, reinforced the importance of classic driver mutations in gastric cancer pathogenesis, and led to the discovery of new driver gene mutations that previously were not known to be associated with gastric cancer. This wealth of genomic data has significant potential to impact the future management of this disease, and the challenge remains to effectively translate this genomic data into better treatment paradigms for gastric cancer. |
format | Online Article Text |
id | pubmed-5331775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53317752017-03-08 Gastric Cancer Genomics: Advances and Future Directions Katona, Bryson W. Rustgi, Anil K. Cell Mol Gastroenterol Hepatol Review Advancement in the field of cancer genomics is revolutionizing the molecular characterization of a wide variety of different cancers. Recent application of large-scale, next-generation sequencing technology to gastric cancer, which remains a major source of morbidity and mortality throughout the world, has helped better define the complex genomic landscape of this cancer. These studies also have led to the development of novel genomically based molecular classification systems for gastric cancer, reinforced the importance of classic driver mutations in gastric cancer pathogenesis, and led to the discovery of new driver gene mutations that previously were not known to be associated with gastric cancer. This wealth of genomic data has significant potential to impact the future management of this disease, and the challenge remains to effectively translate this genomic data into better treatment paradigms for gastric cancer. Elsevier 2017-01-14 /pmc/articles/PMC5331775/ /pubmed/28275688 http://dx.doi.org/10.1016/j.jcmgh.2017.01.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Katona, Bryson W. Rustgi, Anil K. Gastric Cancer Genomics: Advances and Future Directions |
title | Gastric Cancer Genomics: Advances and Future Directions |
title_full | Gastric Cancer Genomics: Advances and Future Directions |
title_fullStr | Gastric Cancer Genomics: Advances and Future Directions |
title_full_unstemmed | Gastric Cancer Genomics: Advances and Future Directions |
title_short | Gastric Cancer Genomics: Advances and Future Directions |
title_sort | gastric cancer genomics: advances and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331775/ https://www.ncbi.nlm.nih.gov/pubmed/28275688 http://dx.doi.org/10.1016/j.jcmgh.2017.01.003 |
work_keys_str_mv | AT katonabrysonw gastriccancergenomicsadvancesandfuturedirections AT rustgianilk gastriccancergenomicsadvancesandfuturedirections |