Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in Mice

BACKGROUND & AIMS: Hepatic cholesterol accumulation and autophagy defects contribute to hepatocyte injury in fatty liver disease. Bile acid synthesis is a major pathway for cholesterol catabolism in the liver. This study aims to understand the molecular link between cholesterol and bile acid met...

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Detalles Bibliográficos
Autores principales: Wang, Yifeng, Ding, Yifeng, Li, Jibiao, Chavan, Hemantkumar, Matye, David, Ni, Hong-Min, Chiang, John Y.L., Krishnamurthy, Partha, Ding, Wen-Xing, Li, Tiangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331786/
https://www.ncbi.nlm.nih.gov/pubmed/28275691
http://dx.doi.org/10.1016/j.jcmgh.2016.10.002

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