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Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation

Maternal smoking and micronutrient intake during pregnancy are two strong biological candidates for impacting the developing epigenome. The extent to which DNA methylation in offspring is modified by these intrauterine exposures has not been presented in parallel. In this review, we summarize human...

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Detalles Bibliográficos
Autores principales: Richmond, Rebecca C, Joubert, Bonnie R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331918/
https://www.ncbi.nlm.nih.gov/pubmed/28234021
http://dx.doi.org/10.2217/epi-2016-0135
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author Richmond, Rebecca C
Joubert, Bonnie R
author_facet Richmond, Rebecca C
Joubert, Bonnie R
author_sort Richmond, Rebecca C
collection PubMed
description Maternal smoking and micronutrient intake during pregnancy are two strong biological candidates for impacting the developing epigenome. The extent to which DNA methylation in offspring is modified by these intrauterine exposures has not been presented in parallel. In this review, we summarize human studies which have investigated genome-wide DNA methylation in the offspring in relation to maternal smoking and one-carbon micronutrient exposure during pregnancy. We contrast the primarily independent efforts for these two categories of exposure, and potential explanations for these differences. We emphasize methodological considerations such as power to detect methylation signals, exposure assessment, control of sources of variability, causal inference and the role of observed methylation changes in mediating downstream outcomes in the offspring.
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spelling pubmed-53319182017-11-08 Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation Richmond, Rebecca C Joubert, Bonnie R Epigenomics Review Maternal smoking and micronutrient intake during pregnancy are two strong biological candidates for impacting the developing epigenome. The extent to which DNA methylation in offspring is modified by these intrauterine exposures has not been presented in parallel. In this review, we summarize human studies which have investigated genome-wide DNA methylation in the offspring in relation to maternal smoking and one-carbon micronutrient exposure during pregnancy. We contrast the primarily independent efforts for these two categories of exposure, and potential explanations for these differences. We emphasize methodological considerations such as power to detect methylation signals, exposure assessment, control of sources of variability, causal inference and the role of observed methylation changes in mediating downstream outcomes in the offspring. Future Medicine Ltd 2017-03 2017-02-17 /pmc/articles/PMC5331918/ /pubmed/28234021 http://dx.doi.org/10.2217/epi-2016-0135 Text en © 2017 Rebecca C Richmond This work is licensed under the Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Richmond, Rebecca C
Joubert, Bonnie R
Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title_full Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title_fullStr Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title_full_unstemmed Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title_short Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation
title_sort contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring dna methylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331918/
https://www.ncbi.nlm.nih.gov/pubmed/28234021
http://dx.doi.org/10.2217/epi-2016-0135
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