Novel CD28 antagonist mPEG PV1-Fab’ mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production

Autoimmune Uveitis is an important chronic inflammatory disease and a leading cause of impaired vision and blindness. This ocular autoimmune disorder is mainly mediated by T CD4(+) lymphocytes poising a T(H)1 phenotype. Costimulatory molecules are known to play an important role on T cell activation...

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Detalles Bibliográficos
Autores principales: Papotto, Pedro Henrique, Marengo, Eliana Blini, Sardinha, Luiz Roberto, Carvalho, Karina Inácio, de Carvalho, Ana Eduarda Zulim, Castillo-Mendez, Sheyla, Jank, Carina Calixto, Vanhove, Bernard, Goldberg, Anna Carla, Rizzo, Luiz Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331984/
https://www.ncbi.nlm.nih.gov/pubmed/28248972
http://dx.doi.org/10.1371/journal.pone.0171822

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