The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA7 and HoxA9

Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy caused by a variety of mutations, including genes encoding the cohesin complex. Recent studies have demonstrated that reduction in cohesin complex levels leads to enhanced self-renewal in hematopoietic stem and progenitors (HSP...

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Detalles Bibliográficos
Autores principales: Fisher, Joseph B., Peterson, Jonathan, Reimer, Michael, Stelloh, Cary, Pulakanti, Kirthi, Gerbec, Zachary J., Abel, Alex M., Strouse, Jennifer Miksanek, Strouse, Christopher, McNulty, Maureen, Malarkannan, Subramaniam, Crispino, John D., Milanovich, Samuel, Rao, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332284/
https://www.ncbi.nlm.nih.gov/pubmed/27554164
http://dx.doi.org/10.1038/leu.2016.240

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