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Potential Role of Chemokines in Fracture Repair
Chemokines are a family of small cytokines that share a typical key structure that is stabilized by disulfide bonds between the cysteine residues at the NH(2)-terminal of the protein, and they are secreted by a great variety of cells in several different conditions. Their function is directly depend...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332385/ https://www.ncbi.nlm.nih.gov/pubmed/28303118 http://dx.doi.org/10.3389/fendo.2017.00039 |
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author | Edderkaoui, Bouchra |
author_facet | Edderkaoui, Bouchra |
author_sort | Edderkaoui, Bouchra |
collection | PubMed |
description | Chemokines are a family of small cytokines that share a typical key structure that is stabilized by disulfide bonds between the cysteine residues at the NH(2)-terminal of the protein, and they are secreted by a great variety of cells in several different conditions. Their function is directly dependent on their interactions with their receptors. Chemokines are involved in cell maturation and differentiation, infection, autoimmunity, cancer, and, in general, in any situation where immune components are involved. However, their role in postfracture inflammation and fracture healing is not yet well established. In this article, we will discuss the response of chemokines to bone fracture and their potential roles in postfracture inflammation and healing based on data from our studies and from other previously published studies. |
format | Online Article Text |
id | pubmed-5332385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53323852017-03-16 Potential Role of Chemokines in Fracture Repair Edderkaoui, Bouchra Front Endocrinol (Lausanne) Endocrinology Chemokines are a family of small cytokines that share a typical key structure that is stabilized by disulfide bonds between the cysteine residues at the NH(2)-terminal of the protein, and they are secreted by a great variety of cells in several different conditions. Their function is directly dependent on their interactions with their receptors. Chemokines are involved in cell maturation and differentiation, infection, autoimmunity, cancer, and, in general, in any situation where immune components are involved. However, their role in postfracture inflammation and fracture healing is not yet well established. In this article, we will discuss the response of chemokines to bone fracture and their potential roles in postfracture inflammation and healing based on data from our studies and from other previously published studies. Frontiers Media S.A. 2017-03-02 /pmc/articles/PMC5332385/ /pubmed/28303118 http://dx.doi.org/10.3389/fendo.2017.00039 Text en Copyright © 2017 Edderkaoui. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Edderkaoui, Bouchra Potential Role of Chemokines in Fracture Repair |
title | Potential Role of Chemokines in Fracture Repair |
title_full | Potential Role of Chemokines in Fracture Repair |
title_fullStr | Potential Role of Chemokines in Fracture Repair |
title_full_unstemmed | Potential Role of Chemokines in Fracture Repair |
title_short | Potential Role of Chemokines in Fracture Repair |
title_sort | potential role of chemokines in fracture repair |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332385/ https://www.ncbi.nlm.nih.gov/pubmed/28303118 http://dx.doi.org/10.3389/fendo.2017.00039 |
work_keys_str_mv | AT edderkaouibouchra potentialroleofchemokinesinfracturerepair |