Caloric Restriction Is More Efficient than Physical Exercise to Protect from Cisplatin Nephrotoxicity via PPAR-Alpha Activation

The antineoplastic drug cisplatin promotes renal injury, which limits its use. Protocols that reduce renal cisplatin toxicity will allow higher doses to be used in cisplatin treatment. Here, we compare physical exercise and caloric restriction (CR) as protocols to reduce cisplatin renal injury in mi...

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Detalles Bibliográficos
Autores principales: Estrela, Gabriel R., Wasinski, Frederick, Batista, Rogério O., Hiyane, Meire I., Felizardo, Raphael J. F., Cunha, Flavia, de Almeida, Danilo C., Malheiros, Denise M. A. C., Câmara, Niels O. S., Barros, Carlos C., Bader, Michael, Araujo, Ronaldo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332405/
https://www.ncbi.nlm.nih.gov/pubmed/28303105
http://dx.doi.org/10.3389/fphys.2017.00116

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