Cargando…

Expansions of Cytotoxic CD4(+)CD28(−) T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection

A large proportion of cardiovascular (CV) pathology results from immune-mediated damage, including systemic inflammation and cellular proliferation, which cause a narrowing of the blood vessels. Expansions of cytotoxic CD4(+) T cells characterized by loss of CD28 (“CD4(+)CD28(−) T cells” or “CD4(+)C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Broadley, Iain, Pera, Alejandra, Morrow, George, Davies, Kevin A., Kern, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332470/ https://www.ncbi.nlm.nih.gov/pubmed/28303136 http://dx.doi.org/10.3389/fimmu.2017.00195

Ejemplares similares

CD28(null) pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death
por: Pera, Alejandra, et al.
Publicado: (2018)

CD28 (null) CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection
por: Bano, Aalia, et al.
Publicado: (2019)

CMV Latent Infection Improves CD8+ T Response to SEB Due to Expansion of Polyfunctional CD57+ Cells in Young Individuals
por: Pera, Alejandra, et al.
Publicado: (2014)

The expansion of CD4(+)CD28(- )T cells in patients with rheumatoid arthritis
por: Pawlik, Andrzej, et al.
Publicado: (2003)

Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets
por: Lopez-Sejas, Nelson, et al.
Publicado: (2016)

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians
por: Martin-Ruiz, Carmen, et al.
Publicado: (2020)

Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis
por: Zhang, Ti, et al.
Publicado: (2022)

CMV Status Drives Distinct Trajectories of CD4+ T Cell Differentiation
por: Zhang, Weiwen, et al.
Publicado: (2021)

IL-21 promotes the expansion of CD27(+)CD28(+) tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
por: Santegoets, Saskia JAM, et al.
Publicado: (2013)

Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis
por: Schirmer, Michael, et al.
Publicado: (2002)

In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences
por: Reus, Bernhard, et al.
Publicado: (2021)

Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto’s thyroiditis
por: Prelog, Martina, et al.
Publicado: (2013)

Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis
por: Ledezma-Lozano, I. Y., et al.
Publicado: (2011)

Interleukin-7 and interleukin-15 drive CD4(+)CD28(null) T lymphocyte expansion and function in patients with acute coronary syndrome
por: Bullenkamp, Jessica, et al.
Publicado: (2020)

Marked skewing of entire T-cell memory compartment occurs only in a minority of CMV-infected individuals and is unrelated to the degree of memory subset skewing among CMV-specific T-cells
por: Fuhrmann, Stephan, et al.
Publicado: (2023)

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
Publicado: (1994)

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells
por: Mitra, Ankita, et al.
Publicado: (2020)

CD28(−) Cells Are Increased in Early Rheumatoid Arthritis and Are Linked With Cytomegalovirus Status
por: Thompson, Charlotte, et al.
Publicado: (2020)

Correction: CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals
Publicado: (2014)

Skewed distribution of proinflammatory CD4(+)CD28(null )T cells in rheumatoid arthritis
por: Fasth, Andreas ER, et al.
Publicado: (2007)

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals
por: Liaskou, Evaggelia, et al.
Publicado: (2017)

Genetic variants at CD28, PRDM1, and CD2/CD58 are associated with rheumatoid arthritis risk
por: Raychaudhuri, Soumya, et al.
Publicado: (2009)

Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key?
por: Mueller, Matthias C., et al.
Publicado: (2021)

Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28(null) T Lymphocytes in Rheumatoid Arthritis Disease
por: Rioseras, Beatriz, et al.
Publicado: (2021)

Enrichment of CD8+ CD28- cytotoxic T cells in circulating lymphocytes of patients with ankylosing spondylitis
por: Schirmer, M, et al.
Publicado: (2001)

Reduced Ebola vaccine responses in CMV(+) young adults is associated with expansion of CD57(+)KLRG1(+) T cells
por: Bowyer, Georgina, et al.
Publicado: (2020)

Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation
por: Munks, Michael W., et al.
Publicado: (2023)

CMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia
por: Higdon, Lauren E., et al.
Publicado: (2022)

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
por: Pita-Lopez, María Luisa, et al.
Publicado: (2009)

The hallmarks of CMV-specific CD8 T-cell differentiation
por: van den Berg, Sara P. H., et al.
Publicado: (2019)

Subclinical Reactivation of Cytomegalovirus Drives CD4(+)CD28(null) T-Cell Expansion and Impaired Immune Response to Pneumococcal Vaccination in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
por: Chanouzas, Dimitrios, et al.
Publicado: (2019)

CD107a Expression and IFN-γ Production as Markers for Evaluation of Cytotoxic CD3+ CD8+ T Cell Response to CMV Antigen in Women with Recurrent Spontaneous Abortion
por: Tarokhian, Batoul, et al.
Publicado: (2014)

CD28(−) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men
por: Vuddamalay, Yirajen, et al.
Publicado: (2017)

Prevalence, clinical relevance and characterization of circulating cytotoxic CD4(+)CD28(- )T cells in ankylosing spondylitis
por: Duftner, Christina, et al.
Publicado: (2003)

CD28nullCD4(+ )T cells: an effector memory T cell population in patients with rheumatoid arthritis
por: Fasth, AER, et al.
Publicado: (2004)

T cell stimulation and expansion by SunTag-based clustering of anti-CD3/CD28 scFv
por: Zhong, Kunhong, et al.
Publicado: (2020)

Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells
por: Kirkham, Frances, et al.
Publicado: (2021)

CMV and Triggers of Systemic Sclerosis
Publicado: (2006)

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help
Publicado: (1993)

Minimal hepatic encephalopathy is associated with expansion and activation of CD(4+)CD28(−), Th22 and Tfh and B lymphocytes
por: Mangas-Losada, Alba, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_um5h0fqti83r0pbh3u8230h560