Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, frequently metastatic sarcomas that are associated with neurofibromatosis type 1 (NF1), a prominent inherited genetic disease in humans. Although loss of the NF1 gene predisposes to MPNST induction, relatively long tumor latency in NF...

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Detalles Bibliográficos
Autores principales: Ki, D H, He, S, Rodig, S, Look, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332555/
https://www.ncbi.nlm.nih.gov/pubmed/27477693
http://dx.doi.org/10.1038/onc.2016.269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332555/
https://www.ncbi.nlm.nih.gov/pubmed/27477693
http://dx.doi.org/10.1038/onc.2016.269

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