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Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

Osteogenic differentiation is crucial for the maintenance of bone homeostasis. Sirtuin 3 (SIRT3), a member of sirtuins family, functions as a critical deacetylase that regulates many key proteins. In the current study, we aimed to clarify the role of SIRT3 in osteogenic differentiation and the possi...

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Detalles Bibliográficos
Autores principales: Ding, Yong, Yang, Hongmei, Wang, Yucai, Chen, Jun, Ji, Zhenwei, Sun, Honghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332879/
https://www.ncbi.nlm.nih.gov/pubmed/28255277
http://dx.doi.org/10.7150/ijbs.17053