Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We revie...

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Detalles Bibliográficos
Autores principales: Lusk, Jay B., Lam, Vanessa Y. M., Tolwinski, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332939/
https://www.ncbi.nlm.nih.gov/pubmed/28178204
http://dx.doi.org/10.3390/cancers9020016
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author Lusk, Jay B.
Lam, Vanessa Y. M.
Tolwinski, Nicholas S.
author_facet Lusk, Jay B.
Lam, Vanessa Y. M.
Tolwinski, Nicholas S.
author_sort Lusk, Jay B.
collection PubMed
description EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer.
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spelling pubmed-53329392017-03-13 Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer Lusk, Jay B. Lam, Vanessa Y. M. Tolwinski, Nicholas S. Cancers (Basel) Review EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer. MDPI 2017-02-07 /pmc/articles/PMC5332939/ /pubmed/28178204 http://dx.doi.org/10.3390/cancers9020016 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lusk, Jay B.
Lam, Vanessa Y. M.
Tolwinski, Nicholas S.
Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title_full Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title_fullStr Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title_full_unstemmed Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title_short Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer
title_sort epidermal growth factor pathway signaling in drosophila embryogenesis: tools for understanding cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332939/
https://www.ncbi.nlm.nih.gov/pubmed/28178204
http://dx.doi.org/10.3390/cancers9020016
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