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A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus

Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently...

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Autor principal: Smyth, Victoria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332948/
https://www.ncbi.nlm.nih.gov/pubmed/28208602
http://dx.doi.org/10.3390/v9020029
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author Smyth, Victoria J.
author_facet Smyth, Victoria J.
author_sort Smyth, Victoria J.
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description Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agent, namely severe kidney disease of young broilers with visceral gout and the “White Chicks” hatchery disease. Examination of the strains of CAstV associated with the two latter diseases reveals they are closely related genetically. This review will discuss the pathogenesis of CAstV in relation to strain diversity and the effects of vertical versus horizontal transmission, virus load, co-infections and age of bird at infection, all factors that may impact upon disease severity.
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spelling pubmed-53329482017-03-13 A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus Smyth, Victoria J. Viruses Review Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agent, namely severe kidney disease of young broilers with visceral gout and the “White Chicks” hatchery disease. Examination of the strains of CAstV associated with the two latter diseases reveals they are closely related genetically. This review will discuss the pathogenesis of CAstV in relation to strain diversity and the effects of vertical versus horizontal transmission, virus load, co-infections and age of bird at infection, all factors that may impact upon disease severity. MDPI 2017-02-10 /pmc/articles/PMC5332948/ /pubmed/28208602 http://dx.doi.org/10.3390/v9020029 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smyth, Victoria J.
A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title_full A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title_fullStr A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title_full_unstemmed A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title_short A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus
title_sort review of the strain diversity and pathogenesis of chicken astrovirus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332948/
https://www.ncbi.nlm.nih.gov/pubmed/28208602
http://dx.doi.org/10.3390/v9020029
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