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Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases

Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates....

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Autores principales: Trulioff, Andrey, Ermakov, Alexander, Malashichev, Yegor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333037/
https://www.ncbi.nlm.nih.gov/pubmed/28125008
http://dx.doi.org/10.3390/genes8020048
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author Trulioff, Andrey
Ermakov, Alexander
Malashichev, Yegor
author_facet Trulioff, Andrey
Ermakov, Alexander
Malashichev, Yegor
author_sort Trulioff, Andrey
collection PubMed
description Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry.
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spelling pubmed-53330372017-03-13 Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases Trulioff, Andrey Ermakov, Alexander Malashichev, Yegor Genes (Basel) Review Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry. MDPI 2017-01-25 /pmc/articles/PMC5333037/ /pubmed/28125008 http://dx.doi.org/10.3390/genes8020048 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trulioff, Andrey
Ermakov, Alexander
Malashichev, Yegor
Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title_full Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title_fullStr Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title_full_unstemmed Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title_short Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
title_sort primary cilia as a possible link between left-right asymmetry and neurodevelopmental diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333037/
https://www.ncbi.nlm.nih.gov/pubmed/28125008
http://dx.doi.org/10.3390/genes8020048
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