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Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases
Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333037/ https://www.ncbi.nlm.nih.gov/pubmed/28125008 http://dx.doi.org/10.3390/genes8020048 |
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author | Trulioff, Andrey Ermakov, Alexander Malashichev, Yegor |
author_facet | Trulioff, Andrey Ermakov, Alexander Malashichev, Yegor |
author_sort | Trulioff, Andrey |
collection | PubMed |
description | Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry. |
format | Online Article Text |
id | pubmed-5333037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53330372017-03-13 Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases Trulioff, Andrey Ermakov, Alexander Malashichev, Yegor Genes (Basel) Review Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry. MDPI 2017-01-25 /pmc/articles/PMC5333037/ /pubmed/28125008 http://dx.doi.org/10.3390/genes8020048 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Trulioff, Andrey Ermakov, Alexander Malashichev, Yegor Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title_full | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title_fullStr | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title_full_unstemmed | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title_short | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases |
title_sort | primary cilia as a possible link between left-right asymmetry and neurodevelopmental diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333037/ https://www.ncbi.nlm.nih.gov/pubmed/28125008 http://dx.doi.org/10.3390/genes8020048 |
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