Solving the Telomere Replication Problem

Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication pr...

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Detalles Bibliográficos
Autores principales: Maestroni, Laetitia, Matmati, Samah, Coulon, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333044/
https://www.ncbi.nlm.nih.gov/pubmed/28146113
http://dx.doi.org/10.3390/genes8020055
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author Maestroni, Laetitia
Matmati, Samah
Coulon, Stéphane
author_facet Maestroni, Laetitia
Matmati, Samah
Coulon, Stéphane
author_sort Maestroni, Laetitia
collection PubMed
description Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity.
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spelling pubmed-53330442017-03-13 Solving the Telomere Replication Problem Maestroni, Laetitia Matmati, Samah Coulon, Stéphane Genes (Basel) Review Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromosomes. This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can threaten the integrity of telomeres, will be reviewed. In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity. MDPI 2017-01-31 /pmc/articles/PMC5333044/ /pubmed/28146113 http://dx.doi.org/10.3390/genes8020055 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maestroni, Laetitia
Matmati, Samah
Coulon, Stéphane
Solving the Telomere Replication Problem
title Solving the Telomere Replication Problem
title_full Solving the Telomere Replication Problem
title_fullStr Solving the Telomere Replication Problem
title_full_unstemmed Solving the Telomere Replication Problem
title_short Solving the Telomere Replication Problem
title_sort solving the telomere replication problem
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333044/
https://www.ncbi.nlm.nih.gov/pubmed/28146113
http://dx.doi.org/10.3390/genes8020055
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