A Critical Balance: dNTPs and the Maintenance of Genome Stability

A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected...

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Detalles Bibliográficos
Autores principales: Pai, Chen-Chun, Kearsey, Stephen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333046/
https://www.ncbi.nlm.nih.gov/pubmed/28146119
http://dx.doi.org/10.3390/genes8020057
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author Pai, Chen-Chun
Kearsey, Stephen E.
author_facet Pai, Chen-Chun
Kearsey, Stephen E.
author_sort Pai, Chen-Chun
collection PubMed
description A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.
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spelling pubmed-53330462017-03-13 A Critical Balance: dNTPs and the Maintenance of Genome Stability Pai, Chen-Chun Kearsey, Stephen E. Genes (Basel) Review A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability. MDPI 2017-01-31 /pmc/articles/PMC5333046/ /pubmed/28146119 http://dx.doi.org/10.3390/genes8020057 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pai, Chen-Chun
Kearsey, Stephen E.
A Critical Balance: dNTPs and the Maintenance of Genome Stability
title A Critical Balance: dNTPs and the Maintenance of Genome Stability
title_full A Critical Balance: dNTPs and the Maintenance of Genome Stability
title_fullStr A Critical Balance: dNTPs and the Maintenance of Genome Stability
title_full_unstemmed A Critical Balance: dNTPs and the Maintenance of Genome Stability
title_short A Critical Balance: dNTPs and the Maintenance of Genome Stability
title_sort critical balance: dntps and the maintenance of genome stability
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333046/
https://www.ncbi.nlm.nih.gov/pubmed/28146119
http://dx.doi.org/10.3390/genes8020057
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