Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity

Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in humans. Here we conduct a GWAS of NSCLP with multiple independent replications, totalling 7,404 NSOFC cases and 16,059 cont...

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Detalles Bibliográficos
Autores principales: Yu, Yanqin, Zuo, Xianbo, He, Miao, Gao, Jinping, Fu, Yuchuan, Qin, Chuanqi, Meng, Liuyan, Wang, Wenjun, Song, Yaling, Cheng, Yong, Zhou, Fusheng, Chen, Gang, Zheng, Xiaodong, Wang, Xinhuan, Liang, Bo, Zhu, Zhengwei, Fu, Xiazhou, Sheng, Yujun, Hao, Jiebing, Liu, Zhongyin, Yan, Hansong, Mangold, Elisabeth, Ruczinski, Ingo, Liu, Jianjun, Marazita, Mary L., Ludwig, Kerstin U., Beaty, Terri H., Zhang, Xuejun, Sun, Liangdan, Bian, Zhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333091/
https://www.ncbi.nlm.nih.gov/pubmed/28232668
http://dx.doi.org/10.1038/ncomms14364

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