Computational modeling of the cell-autonomous mammalian circadian oscillator

This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the...

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Autores principales: Podkolodnaya, Olga A., Tverdokhleb, Natalya N., Podkolodnyy, Nikolay L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333193/
https://www.ncbi.nlm.nih.gov/pubmed/28466791
http://dx.doi.org/10.1186/s12918-016-0379-8
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author Podkolodnaya, Olga A.
Tverdokhleb, Natalya N.
Podkolodnyy, Nikolay L.
author_facet Podkolodnaya, Olga A.
Tverdokhleb, Natalya N.
Podkolodnyy, Nikolay L.
author_sort Podkolodnaya, Olga A.
collection PubMed
description This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12918-016-0379-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-53331932017-03-06 Computational modeling of the cell-autonomous mammalian circadian oscillator Podkolodnaya, Olga A. Tverdokhleb, Natalya N. Podkolodnyy, Nikolay L. BMC Syst Biol Review This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12918-016-0379-8) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-24 /pmc/articles/PMC5333193/ /pubmed/28466791 http://dx.doi.org/10.1186/s12918-016-0379-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Podkolodnaya, Olga A.
Tverdokhleb, Natalya N.
Podkolodnyy, Nikolay L.
Computational modeling of the cell-autonomous mammalian circadian oscillator
title Computational modeling of the cell-autonomous mammalian circadian oscillator
title_full Computational modeling of the cell-autonomous mammalian circadian oscillator
title_fullStr Computational modeling of the cell-autonomous mammalian circadian oscillator
title_full_unstemmed Computational modeling of the cell-autonomous mammalian circadian oscillator
title_short Computational modeling of the cell-autonomous mammalian circadian oscillator
title_sort computational modeling of the cell-autonomous mammalian circadian oscillator
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333193/
https://www.ncbi.nlm.nih.gov/pubmed/28466791
http://dx.doi.org/10.1186/s12918-016-0379-8
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