Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates gluconeogenesis. Low Nur77 expression in clinical HCC samples correlates with poor prognosis...

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Detalles Bibliográficos
Autores principales: Bian, Xue-li, Chen, Hang-zi, Yang, Peng-bo, Li, Ying-ping, Zhang, Fen-na, Zhang, Jia-yuan, Wang, Wei-jia, Zhao, Wen-xiu, Zhang, Sheng, Chen, Qi-tao, Zheng, Yu, Sun, Xiao-yu, Wang, Xiao-min, Chien, Kun-Yi, Wu, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333363/
https://www.ncbi.nlm.nih.gov/pubmed/28240261
http://dx.doi.org/10.1038/ncomms14420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333363/
https://www.ncbi.nlm.nih.gov/pubmed/28240261
http://dx.doi.org/10.1038/ncomms14420

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