Assessing histone demethylase inhibitors in cells: lessons learned

BACKGROUND: Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The first KDM inhibitors for KDM1 have entered clinical trials, and efforts are ong...

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Detalles Bibliográficos
Autores principales: Hatch, Stephanie B., Yapp, Clarence, Montenegro, Raquel C., Savitsky, Pavel, Gamble, Vicki, Tumber, Anthony, Ruda, Gian Filippo, Bavetsias, Vassilios, Fedorov, Oleg, Atrash, Butrus, Raynaud, Florence, Lanigan, Rachel, Carmichael, LeAnne, Tomlin, Kathy, Burke, Rosemary, Westaway, Susan M., Brown, Jack A., Prinjha, Rab K., Martinez, Elisabeth D., Oppermann, Udo, Schofield, Christopher J., Bountra, Chas, Kawamura, Akane, Blagg, Julian, Brennan, Paul E., Rossanese, Olivia, Müller, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333395/
https://www.ncbi.nlm.nih.gov/pubmed/28265301
http://dx.doi.org/10.1186/s13072-017-0116-6

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