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ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data
Next-generation sequencing (NGS) of bulk tumour tissue can identify constituent cell populations in cancers and measure their abundance. This requires computational deconvolution of allelic counts from somatic mutations, which may be incapable of fully resolving the underlying population structure....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333399/ https://www.ncbi.nlm.nih.gov/pubmed/28249593 http://dx.doi.org/10.1186/s13059-017-1169-3 |