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Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study

BACKGROUND: Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among n...

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Autores principales: Zhang, Ming, Wang, Bingyuan, Liu, Yu, Sun, Xizhuo, Luo, Xinping, Wang, Chongjian, Li, Linlin, Zhang, Lu, Ren, Yongcheng, Zhao, Yang, Zhou, Junmei, Han, Chengyi, Zhao, Jingzhi, Hu, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333419/
https://www.ncbi.nlm.nih.gov/pubmed/28249577
http://dx.doi.org/10.1186/s12933-017-0514-x
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author Zhang, Ming
Wang, Bingyuan
Liu, Yu
Sun, Xizhuo
Luo, Xinping
Wang, Chongjian
Li, Linlin
Zhang, Lu
Ren, Yongcheng
Zhao, Yang
Zhou, Junmei
Han, Chengyi
Zhao, Jingzhi
Hu, Dongsheng
author_facet Zhang, Ming
Wang, Bingyuan
Liu, Yu
Sun, Xizhuo
Luo, Xinping
Wang, Chongjian
Li, Linlin
Zhang, Lu
Ren, Yongcheng
Zhao, Yang
Zhou, Junmei
Han, Chengyi
Zhao, Jingzhi
Hu, Dongsheng
author_sort Zhang, Ming
collection PubMed
description BACKGROUND: Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among normal-weight people in rural China. METHODS: We included data from 5706 people with normal body mass index (BMI) (18.5–23.9 kg/m(2)) without baseline T2DM in a rural Chinese cohort followed for a median of 6.0 years. A Cox proportional-hazard model was used to assess the risk of incident T2DM by quartiles of TyG index and difference in TyG index between follow-up and baseline (TyG-D), estimating hazard ratios (HRs) and 95% confidence intervals (CIs). A generalized additive plot was used to show the nonparametric smoothed exposure–response association between risk of T2DM and TyG index as a continuous variable. TyG was calculated as ln [fasting triglyceride level (mg/dl) × fasting plasma glucose level (mg/dl)/2]. RESULTS: Risk of incident T2DM was increased with quartiles 2, 3 and 4 versus quartile 1 of TyG index (adjusted HR [aHR] 2.48 [95% CI 1.20–5.11], 3.77 [1.83–7.79], and 5.30 [2.21–12.71], P (trend) < 0.001 across quartiles of TyG index). Risk of incident T2DM was increased with quartile 4 versus quartile 1 of TyG-D (aHR 3.91 [2.22–6.87]). The results were consistent when analyses were restricted to participants without baseline metabolic syndrome and impaired fasting glucose level. The generalized additive plot showed cumulative increased risk of T2DM with increasing TyG index. CONCLUSIONS: Risk of incident T2DM is increased with increasing TyG index among rural Chinese people, so the index might be an important indicator for identifying people at high risk of T2DM.
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spelling pubmed-53334192017-03-06 Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study Zhang, Ming Wang, Bingyuan Liu, Yu Sun, Xizhuo Luo, Xinping Wang, Chongjian Li, Linlin Zhang, Lu Ren, Yongcheng Zhao, Yang Zhou, Junmei Han, Chengyi Zhao, Jingzhi Hu, Dongsheng Cardiovasc Diabetol Original Investigation BACKGROUND: Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among normal-weight people in rural China. METHODS: We included data from 5706 people with normal body mass index (BMI) (18.5–23.9 kg/m(2)) without baseline T2DM in a rural Chinese cohort followed for a median of 6.0 years. A Cox proportional-hazard model was used to assess the risk of incident T2DM by quartiles of TyG index and difference in TyG index between follow-up and baseline (TyG-D), estimating hazard ratios (HRs) and 95% confidence intervals (CIs). A generalized additive plot was used to show the nonparametric smoothed exposure–response association between risk of T2DM and TyG index as a continuous variable. TyG was calculated as ln [fasting triglyceride level (mg/dl) × fasting plasma glucose level (mg/dl)/2]. RESULTS: Risk of incident T2DM was increased with quartiles 2, 3 and 4 versus quartile 1 of TyG index (adjusted HR [aHR] 2.48 [95% CI 1.20–5.11], 3.77 [1.83–7.79], and 5.30 [2.21–12.71], P (trend) < 0.001 across quartiles of TyG index). Risk of incident T2DM was increased with quartile 4 versus quartile 1 of TyG-D (aHR 3.91 [2.22–6.87]). The results were consistent when analyses were restricted to participants without baseline metabolic syndrome and impaired fasting glucose level. The generalized additive plot showed cumulative increased risk of T2DM with increasing TyG index. CONCLUSIONS: Risk of incident T2DM is increased with increasing TyG index among rural Chinese people, so the index might be an important indicator for identifying people at high risk of T2DM. BioMed Central 2017-03-01 /pmc/articles/PMC5333419/ /pubmed/28249577 http://dx.doi.org/10.1186/s12933-017-0514-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Zhang, Ming
Wang, Bingyuan
Liu, Yu
Sun, Xizhuo
Luo, Xinping
Wang, Chongjian
Li, Linlin
Zhang, Lu
Ren, Yongcheng
Zhao, Yang
Zhou, Junmei
Han, Chengyi
Zhao, Jingzhi
Hu, Dongsheng
Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title_full Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title_fullStr Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title_full_unstemmed Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title_short Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
title_sort cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: the rural chinese cohort study
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333419/
https://www.ncbi.nlm.nih.gov/pubmed/28249577
http://dx.doi.org/10.1186/s12933-017-0514-x
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