A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

BACKGROUND: Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differentiation marker and an established tumor suppressor in multiple cancers, allows...

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Detalles Bibliográficos
Autores principales: Cheng, Joyce Y., Brown, Taylor C., Murtha, Timothy D., Stenman, Adam, Juhlin, C. Christofer, Larsson, Catharina, Healy, James M., Prasad, Manju L., Knoefel, Wolfram T., Krieg, Andreas, Scholl, Ute I., Korah, Reju, Carling, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333434/
https://www.ncbi.nlm.nih.gov/pubmed/28249601
http://dx.doi.org/10.1186/s12885-017-3152-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333434/
https://www.ncbi.nlm.nih.gov/pubmed/28249601
http://dx.doi.org/10.1186/s12885-017-3152-5

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