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Diffusion MRI in the heart
Diffusion MRI provides unique information on the structure, organization, and integrity of the myocardium without the need for exogenous contrast agents. Diffusion MRI in the heart, however, has proven technically challenging because of the intrinsic non‐rigid deformation during the cardiac cycle, d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333463/ https://www.ncbi.nlm.nih.gov/pubmed/26484848 http://dx.doi.org/10.1002/nbm.3426 |
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author | Mekkaoui, Choukri Reese, Timothy G. Jackowski, Marcel P. Bhat, Himanshu Sosnovik, David E. |
author_facet | Mekkaoui, Choukri Reese, Timothy G. Jackowski, Marcel P. Bhat, Himanshu Sosnovik, David E. |
author_sort | Mekkaoui, Choukri |
collection | PubMed |
description | Diffusion MRI provides unique information on the structure, organization, and integrity of the myocardium without the need for exogenous contrast agents. Diffusion MRI in the heart, however, has proven technically challenging because of the intrinsic non‐rigid deformation during the cardiac cycle, displacement of the myocardium due to respiratory motion, signal inhomogeneity within the thorax, and short transverse relaxation times. Recently developed accelerated diffusion‐weighted MR acquisition sequences combined with advanced post‐processing techniques have improved the accuracy and efficiency of diffusion MRI in the myocardium. In this review, we describe the solutions and approaches that have been developed to enable diffusion MRI of the heart in vivo, including a dual‐gated stimulated echo approach, a velocity‐ (M (1)) or an acceleration‐ (M (2)) compensated pulsed gradient spin echo approach, and the use of principal component analysis filtering. The structure of the myocardium and the application of these techniques in ischemic heart disease are also briefly reviewed. The advent of clinical MR systems with stronger gradients will likely facilitate the translation of cardiac diffusion MRI into clinical use. The addition of diffusion MRI to the well‐established set of cardiovascular imaging techniques should lead to new and complementary approaches for the diagnosis and evaluation of patients with heart disease. © 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd. |
format | Online Article Text |
id | pubmed-5333463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53334632017-03-16 Diffusion MRI in the heart Mekkaoui, Choukri Reese, Timothy G. Jackowski, Marcel P. Bhat, Himanshu Sosnovik, David E. NMR Biomed Special Issue Review Articles Diffusion MRI provides unique information on the structure, organization, and integrity of the myocardium without the need for exogenous contrast agents. Diffusion MRI in the heart, however, has proven technically challenging because of the intrinsic non‐rigid deformation during the cardiac cycle, displacement of the myocardium due to respiratory motion, signal inhomogeneity within the thorax, and short transverse relaxation times. Recently developed accelerated diffusion‐weighted MR acquisition sequences combined with advanced post‐processing techniques have improved the accuracy and efficiency of diffusion MRI in the myocardium. In this review, we describe the solutions and approaches that have been developed to enable diffusion MRI of the heart in vivo, including a dual‐gated stimulated echo approach, a velocity‐ (M (1)) or an acceleration‐ (M (2)) compensated pulsed gradient spin echo approach, and the use of principal component analysis filtering. The structure of the myocardium and the application of these techniques in ischemic heart disease are also briefly reviewed. The advent of clinical MR systems with stronger gradients will likely facilitate the translation of cardiac diffusion MRI into clinical use. The addition of diffusion MRI to the well‐established set of cardiovascular imaging techniques should lead to new and complementary approaches for the diagnosis and evaluation of patients with heart disease. © 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd. John Wiley and Sons Inc. 2015-10-20 2017-03 /pmc/articles/PMC5333463/ /pubmed/26484848 http://dx.doi.org/10.1002/nbm.3426 Text en © 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Special Issue Review Articles Mekkaoui, Choukri Reese, Timothy G. Jackowski, Marcel P. Bhat, Himanshu Sosnovik, David E. Diffusion MRI in the heart |
title | Diffusion MRI in the heart |
title_full | Diffusion MRI in the heart |
title_fullStr | Diffusion MRI in the heart |
title_full_unstemmed | Diffusion MRI in the heart |
title_short | Diffusion MRI in the heart |
title_sort | diffusion mri in the heart |
topic | Special Issue Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333463/ https://www.ncbi.nlm.nih.gov/pubmed/26484848 http://dx.doi.org/10.1002/nbm.3426 |
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