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Syndapin bridges the membrane-cytoskeleton divide during furrow extension
BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333522/ http://dx.doi.org/10.1080/19420889.2016.1255832 |
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author | Sherlekar, Aparna Rikhy, Richa |
author_facet | Sherlekar, Aparna Rikhy, Richa |
author_sort | Sherlekar, Aparna |
collection | PubMed |
description | BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family and can bend phospholipid membranes into tubules of various diameters and directly bind actin. The Syndapin SH3 domain can also interact with actin remodelling proteins and modulate cytoskeletal contractility. Pseudocleavage furrow extension in the syncytial division cycles of Drosophila embryos requires the homeostatic control of conserved processes that control plasma membrane tension and actin contractility. We find that Syndapin plays an important role in promoting pseudocleavage furrow extension. We propose a model involving roles for Syndapin in membrane dynamics and direct or indirect effect on the cytoskeleton to explain how it affects pseudocleavage furrow growth, independent of its role in endocytosis. |
format | Online Article Text |
id | pubmed-5333522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-53335222017-03-13 Syndapin bridges the membrane-cytoskeleton divide during furrow extension Sherlekar, Aparna Rikhy, Richa Commun Integr Biol Article Addendum BAR domain proteins can regulate ‘membrane reservoirs’ that provide surface area and buffer membrane tension. Syndapin is an F-BAR and SH3 domain containing protein involved in cytoskeletal remodelling and endocytosis. The Syndapin F-BAR domain is uniquely versatile compared to others in the family and can bend phospholipid membranes into tubules of various diameters and directly bind actin. The Syndapin SH3 domain can also interact with actin remodelling proteins and modulate cytoskeletal contractility. Pseudocleavage furrow extension in the syncytial division cycles of Drosophila embryos requires the homeostatic control of conserved processes that control plasma membrane tension and actin contractility. We find that Syndapin plays an important role in promoting pseudocleavage furrow extension. We propose a model involving roles for Syndapin in membrane dynamics and direct or indirect effect on the cytoskeleton to explain how it affects pseudocleavage furrow growth, independent of its role in endocytosis. Taylor & Francis 2017-02-08 /pmc/articles/PMC5333522/ http://dx.doi.org/10.1080/19420889.2016.1255832 Text en © 2017 IISER. Published with license by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Article Addendum Sherlekar, Aparna Rikhy, Richa Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title_full | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title_fullStr | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title_full_unstemmed | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title_short | Syndapin bridges the membrane-cytoskeleton divide during furrow extension |
title_sort | syndapin bridges the membrane-cytoskeleton divide during furrow extension |
topic | Article Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333522/ http://dx.doi.org/10.1080/19420889.2016.1255832 |
work_keys_str_mv | AT sherlekaraparna syndapinbridgesthemembranecytoskeletondivideduringfurrowextension AT rikhyricha syndapinbridgesthemembranecytoskeletondivideduringfurrowextension |