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MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation

Survival rates for children and adults carrying mutations in the Mixed Lineage Leukemia (MLL) gene continue to have a very poor prognosis. The most common MLL mutation in acute lymphoblastic leukemia is the t(4;11)(q21;q23) chromosome translocation that fuses MLL in-frame with the AF4 gene producing...

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Detalles Bibliográficos
Autores principales:	Godfrey, Laura, Kerry, Jon, Thorne, Ross, Repapi, Emmanouela, Davies, James O.J., Tapia, Marta, Ballabio, Erica, Hughes, Jim R., Geng, Huimin, Konopleva, Marina, Milne, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Inc 2017
Materias:	Malignant Hematopoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333536/ https://www.ncbi.nlm.nih.gov/pubmed/27856324 http://dx.doi.org/10.1016/j.exphem.2016.11.003

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