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Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications

BACKGROUND: Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic age...

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Autores principales: Sikiric, Predrag, Seiwerth, Sven, Rucman, Rudolf, Kolenc, Danijela, Vuletic, Lovorka Batelja, Drmic, Domagoj, Grgic, Tihomir, Strbe, Sanja, Zukanovic, Goran, Crvenkovic, Dalibor, Madzarac, Goran, Rukavina, Iva, Sucic, Mario, Baric, Marko, Starcevic, Neven, Krstonijevic, Zoran, Bencic, Martina Lovric, Filipcic, Igor, Rokotov, Dinko Stancic, Vlainic, Josipa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/
https://www.ncbi.nlm.nih.gov/pubmed/27138887
http://dx.doi.org/10.2174/1570159X13666160502153022
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author Sikiric, Predrag
Seiwerth, Sven
Rucman, Rudolf
Kolenc, Danijela
Vuletic, Lovorka Batelja
Drmic, Domagoj
Grgic, Tihomir
Strbe, Sanja
Zukanovic, Goran
Crvenkovic, Dalibor
Madzarac, Goran
Rukavina, Iva
Sucic, Mario
Baric, Marko
Starcevic, Neven
Krstonijevic, Zoran
Bencic, Martina Lovric
Filipcic, Igor
Rokotov, Dinko Stancic
Vlainic, Josipa
author_facet Sikiric, Predrag
Seiwerth, Sven
Rucman, Rudolf
Kolenc, Danijela
Vuletic, Lovorka Batelja
Drmic, Domagoj
Grgic, Tihomir
Strbe, Sanja
Zukanovic, Goran
Crvenkovic, Dalibor
Madzarac, Goran
Rukavina, Iva
Sucic, Mario
Baric, Marko
Starcevic, Neven
Krstonijevic, Zoran
Bencic, Martina Lovric
Filipcic, Igor
Rokotov, Dinko Stancic
Vlainic, Josipa
author_sort Sikiric, Predrag
collection PubMed
description BACKGROUND: Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice. METHODS: Review of our research on BPC 157 in terms of brain-gut axis. RESULTS: BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157 modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries. CONCLUSION: BPC 157, a gastric peptide, may serve as remedy in various CNS-disorders.
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spelling pubmed-53335852017-05-01 Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications Sikiric, Predrag Seiwerth, Sven Rucman, Rudolf Kolenc, Danijela Vuletic, Lovorka Batelja Drmic, Domagoj Grgic, Tihomir Strbe, Sanja Zukanovic, Goran Crvenkovic, Dalibor Madzarac, Goran Rukavina, Iva Sucic, Mario Baric, Marko Starcevic, Neven Krstonijevic, Zoran Bencic, Martina Lovric Filipcic, Igor Rokotov, Dinko Stancic Vlainic, Josipa Curr Neuropharmacol Article BACKGROUND: Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice. METHODS: Review of our research on BPC 157 in terms of brain-gut axis. RESULTS: BPC 157 may serve as a novel mediator of Robert’s cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157 modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries. CONCLUSION: BPC 157, a gastric peptide, may serve as remedy in various CNS-disorders. Bentham Science Publishers 2016-11 2016-11 /pmc/articles/PMC5333585/ /pubmed/27138887 http://dx.doi.org/10.2174/1570159X13666160502153022 Text en © 2016 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Sikiric, Predrag
Seiwerth, Sven
Rucman, Rudolf
Kolenc, Danijela
Vuletic, Lovorka Batelja
Drmic, Domagoj
Grgic, Tihomir
Strbe, Sanja
Zukanovic, Goran
Crvenkovic, Dalibor
Madzarac, Goran
Rukavina, Iva
Sucic, Mario
Baric, Marko
Starcevic, Neven
Krstonijevic, Zoran
Bencic, Martina Lovric
Filipcic, Igor
Rokotov, Dinko Stancic
Vlainic, Josipa
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title_full Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title_fullStr Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title_full_unstemmed Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title_short Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
title_sort brain-gut axis and pentadecapeptide bpc 157: theoretical and practical implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/
https://www.ncbi.nlm.nih.gov/pubmed/27138887
http://dx.doi.org/10.2174/1570159X13666160502153022
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